72748-99-3Relevant articles and documents
ASYMMETRIC MICHAEL ADDITIONS VIA SAMP-/RAMP-HYDRAZONES ANTI-DIASTEREO- AND ENANTIOSELECTIVE SYNTHESIS OF 3,4-DISUBSTITUTED 5-OXO-ALKANOATES
Enders, Dieter,Papadopoulos, Kyriakos,Rendenbach, Beatrice E.M.,Appel, Rolf,Knoch, Falk
, p. 3491 - 3494 (2007/10/02)
An efficient and highly anti-diastereo-(de=90-100percent) and enantioselective (ee=92-100percent) synthesis of 3,4-disubstituted 5-oxo-alkanoates 3 in good overall chemical yields is described.The procedure involves the asymmetric Michael addition of aldehydes or ketones to enoates via their lithiated SAMP-/RAMP-hydrazones.Both enantiomers are accessible at will.