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CAS

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72766-65-5

N-{3-[(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-methyl-amino]-propyl}-3,N-dimethyl-benzamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 72766-65-5 Structure

  • Basic information

    1. Product Name: N-{3-[(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-methyl-amino]-propyl}-3,N-dimethyl-benzamide
    2. Synonyms: N-{3-[(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-methyl-amino]-propyl}-3,N-dimethyl-benzamide
    3. CAS NO:72766-65-5
    4. Molecular Formula:
    5. Molecular Weight: 423.515
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 72766-65-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-{3-[(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-methyl-amino]-propyl}-3,N-dimethyl-benzamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-{3-[(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-methyl-amino]-propyl}-3,N-dimethyl-benzamide(72766-65-5)
    11. EPA Substance Registry System: N-{3-[(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-methyl-amino]-propyl}-3,N-dimethyl-benzamide(72766-65-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 72766-65-5(Hazardous Substances Data)

72766-65-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 72766-65-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,7,6 and 6 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 72766-65:
(7*7)+(6*2)+(5*7)+(4*6)+(3*6)+(2*6)+(1*5)=155
155 % 10 = 5
So 72766-65-5 is a valid CAS Registry Number.

72766-65-5Downstream Products

72766-65-5Relevant articles and documents

Synthesis and antihypertensive activity of a series of 4-amino-6,7-dimethoxyquinazoline derivatives

Manoury,Binet,Dumas,Lefevre-Borg,Cavero

, p. 19 - 25 (2007/10/02)

A series of N2-[(acylamino)alkyl]-6,7-dimethoxy-2,4-quinazolinediamines was synthesized as potential α1-adrenoceptor antagonists. When administered to spontaneously hypertensive rats at 10 mg/kg po, a number of propanediamine derivatives showed good antihypertensive activity, whereas the ethanediamine derivatives, albeit being structurally more closely related to prazosin, were devoid of this property. The most active derivative, N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro- 2-furancarboxamide hydrochloride, alfuzosin, showed high selectivity for peripheral α1-postjunctional adrenoceptors. At equiactive antihypertensive doses, its effect on the pressor response to postural changes in conscious dog was less marked than that shown by prazosin. In the light of these results, alfuzosin was selected for clinical evaluation.

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