727664-91-7

Basic information

• Product Name: 2-(2,5-dimethylphenyl)-6-fluorobenzo[d]isothiazol-3(2H)-one
• Synonyms: 2-(2,5-dimethylphenyl)-6-fluorobenzo[d]isothiazol-3(2H)-one
• CAS NO: 727664-91-7
• Molecular Weight: 273.331
• Mol File: 727664-91-7.mol

Chemical Properties

• CAS DataBase Reference: 2-(2,5-dimethylphenyl)-6-fluorobenzo[d]isothiazol-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,5-dimethylphenyl)-6-fluorobenzo[d]isothiazol-3(2H)-one(727664-91-7)
• EPA Substance Registry System: 2-(2,5-dimethylphenyl)-6-fluorobenzo[d]isothiazol-3(2H)-one(727664-91-7)

Safety Data

• Hazardous Substances Data: 727664-91-7(Hazardous Substances Data)

Usage

Molecular weight

289.32 g/mol

Structure

Benzothiazole derivative with a fluorine atom and a carbonyl group attached to the benzene ring

Usage

Synthesis of various pharmaceuticals and agrochemicals, potential biological activities (antimicrobial, anticancer, and antiviral properties), building block in organic synthesis, valuable tool in drug discovery and development processes.

Upstream product

• 95-78-3 2,5-Dimethylaniline 
• 81223-43-0 4-fluoro-2-sulfanyl-benzoic acid 
• 81223-44-1 methyl 4-fluoro-2-sulfanyl-benzoate 
• 1622392-95-3 C₁₅H₁₄FNOS 

Relevant articles and documents

Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1

We report the discovery and characterization of a series of benzoisothiazolone inhibitors of PHOSPHO1, a newly identified soluble phosphatase implicated in skeletal mineralization and soft tissue ossification abnormalities. High-throughput screening (HTS)

Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia

We report the discovery and validation of a series of benzoisothiazolones as potent inhibitors of phosphomannose isomerase (PMI), an enzyme that converts mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) and, more importantly, competes wit