Synthesis of N,N'-dimethyl diazacoronands via double-quaternization reaction
α,ω-Tertiary diamines react under high pressure with α,ω-di-lodo compounds to give the cyclic bis-quaternary salts in almost quantitative yields. It is also shown that the same reaction can be carried out under atmospheric-pressure conditions with slightly lower yields. Subsequent demethylation of the bis-quaternary salts with triphenylphosphine affords N,N'-dimethyl diazcoronands in high yield.
Jurczak,Ostaszewski,Salanski,Stankiewicz
p. 1471 - 1477
(2007/10/02)
High-pressure Approach to the Synthesis of N,N'-Dimethyl Diazacoronands
α,ω-Tertiary diamines react under high pressure with α,ω-di-iodo compounds to give the cyclic bis-quaternary salts in almost quantitative yields and their subsequent demethylation with triphenylphosphine affords N,N'-dimethyl diazacoronands in high yield.
Jurczak, Janusz,Ostaszewski, Ryszard,Salanski, Piotr
p. 184 - 185
(2007/10/02)
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