- Chemical and metabolic study of 5-(2-hydroxypropyl)-5-(2-methyl propyl) barbituric acid: Influence of alcohol function in β
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The behaviour of an hydroxybarbiturate is studied in vitro, under biomimetic conditions, and in vivo, in rats and dogs. In these two cases, pyrimidine trione undergoes a ring opening by intramolecular alcoholysis but, in vivo, an hepatic hydroxylation of alkyl chain is followed by a second lactonization into a spiro compound.
- Lafont,Cave,Lambrey,et al.
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p. 163 - 168
(2007/10/02)
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