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728865-23-4

Articles about 728865-23-4Total 4 be found

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COMPOUNDS FOR THE TREATMENT OF BOVINE OR SWINE RESPIRATORY DISEASE
The present invention provides compounds for use in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).
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Page/Page column 157; 158

(2018/07/29)

Antibacterial agents
no abstract published
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(2015/09/22)

Exploring the UDP pocket of LpxC through amino acid analogs
Lipopolysaccharide (LPS) biosynthesis is an attractive antibacterial target as it is both conserved and essential for the survival of key pathogenic bacteria. Lipid A is the hydrophobic anchor for LPS and a key structural component of the outer membrane of Gram-negative bacteria. Lipid A biosynthesis is performed in part by a unique zinc dependent metalloamidase, LpxC (UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase), which catalyzes the first non-reversible step in lipid A biosynthesis. The UDP portion of the LpxC substrate-binding pocket has been relatively unexplored. We have designed and evaluated a series of hydroxamate based inhibitors which explore the SAR of substitutions directed into the UDP pocket with a range of substituted α-amino acid based linkers. We also provide the first wild type structure of Pseudomonas aeruginosa LpxC which was utilized in the design of many of these analogs.
Hale, Michael R.,Hill, Pamela,Lahiri, Sushmita,Miller, Matthew D.,Ross, Philip,Alm, Richard,Gao, Ning,Kutschke, Amy,Johnstone, Michele,Prince, Bryan,Thresher, Jason,Yang, Wei
supporting information
p. 2362 - 2367
(2013/05/09)

ANTIBACTERIAL AGENTS
Antibacterial compounds of formula (I) are provided, as well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.
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(2009/01/24)

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Chemical Properties

Density: 1.33±0.1 g/cm3(Predicted)
Solubility:≥21.85 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
PKA: 9.11±0.40(Predicted)
PSA: 114.62000
LogP: 2.07230

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