728918-63-6Relevant articles and documents
Identification of a novel selective small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) by virtual screening, resynthesis and biological evaluations
Zhu, Kongkai,Jiang, Chengshi,Tao, Hongrui,Liu, Jingqiu,Zhang, Hua,Luo, Cheng
supporting information, p. 1476 - 1483 (2018/04/20)
As one of the most promising anticancer target in protein arginine methyltransferase (PRMT) family, PRMT5 has been drawing more and more attentions, and many efforts have been devoted to develop its inhibitors. In this study, three PRMT5 inhibitors (9, 16