cas 72996-78-2, methyl 4-[(propionyl)phenylamino]piperidine-4-carboxylate

Articles about 72996-78-2Total 5 be found

FENTANYL HAPTENS, FENTANYL HAPTEN CONJUGATES, AND METHODS FOR MAKING AND USING
This disclosure describes fentanyl haptens, a fentanyl hapten-carrier conjugate, methods of making the fentanyl hapten-carrier conjugate, and methods of using the fentanyl hapten-carrier conjugate including, for example, as a prophylactic vaccine to counteract toxicity from exposure to fentanyl, fentanyl derivatives, and fentanyl analogs. In some embodiments, the fentanyl hapten-carrier conjugate or a composition including the fentanyl hapten-carrier conjugate may be used in an anti-opioid vaccine.
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Page/Page column 46; 50

(2021/09/17)

New method for synthesizing carfentanil
The invention belongs to the field of synthesis of organic matters and specifically relates to a method for synthesizing carfentanil. The synthesis method comprises the following steps of taking N-Bocprotective group piperidone as a raw material, and carrying out five steps of performing a Bargellini reaction, N-acylation, methylation, deprotection and N-alkylation to obtain a target product, namely the carfentanil. According to the invention, by adopting the new method for synthesizing the carfentanil, the use of a extremely-toxic substance, namely potassium cyanide, is avoided, so that theenvironment-friendly effect is achieved; the yield is high; a synthesis route is relatively simple; and the requirements of a modern high-efficiency and low-cost synthesis idea can be met.
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(2019/06/08)

Alternate Process for Remifentanil Preparation
An alternate process for synthesizing opiate or opioid analgesics and anesthetics, and intermediates thereof is provided. In particular, a process of synthesizing synthetic opiate or opioid compounds such as, for example, remifentanil, carfentanil, sufentanil, fentanyl, and alfentanil are disclosed.
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Page/Page column 8

(2010/05/13)

A facile method for preparation of [2H3]-sufentanil and its metabolites
An improved process for the synthesis of sufentanil with an overall yield of 26% is described. The reactive and high yielding N-debenzylation of the piperidine intermediate 7 using a mixture of Pd/C and Pd(OH)2 was applied to other drug intermediates affording free amines in short reaction times. The deuterium-labeled sufentanil and the metabolite desmethylsufentanil were synthesized applying the optimized process.
Srimurugan, Sankareswaran,Murugan, Kaliyappan,Chen, Chinpiao
experimental part
p. 1421 - 1424
(2010/06/14)

Syntheses, biological evaluation, and molecular modeling of 18F-labeled 4-anilidopiperidines as μ-opioid receptor imaging agents
The synthesis, evaluation, and molecular modeling of a series of 18F-labeled 4-anilidopiperidines with high affinities for the μ-opioid receptor (μ-OR) are reported. On the basis of the high brain uptake and selective retention in brain regions that contain a high concentration of the μ-OR, combined with a good metabolic stability, [ 18F]fluoro-pentyl carfentanil ([18F]4) and 2-(±)[18F]-fluoropropyl-sufentanil ([18F]6) were selected as the lead compounds for further evaluation. The binding affinity to the human μ-OR was 0.74 and 0.13 nM for [18F]4 and [ 18F]6, respectively. In vitro autoradiography of [18F] 4 and [18F] 6 on rat brain sections produced patterns in accordance with the known distribution of μ-OR expression. Structure-activity relationships of the fluorinated compounds are discussed with respect to the interaction with an activated-state model of the μ-OR. Taken together, the in vivo and in vitro data indicate that [18F] 4 and [18F] 6 hold promise for studying the μ-opioid receptor in humans by means of positron emission tomography.
Henriksen, Gjermund,Platzer, Stefan,Marton, János,Hauser, Andrea,Berthele, Achim,Schwaiger, Markus,Marinelli, Luciana,Lavecchia, Antonio,Novellino, Ettore,Wester, Hans-Jürgen
p. 7720 - 7732
(2007/10/03)