730980-59-3

Basic information

• Product Name: (R)-CHROMAN-4-YLAMINE HYDROCHLORIDE
• Synonyms: (R)-CHROMAN-4-YLAMINE HYDROCHLORIDE;2H-1-Benzopyran-4-amine, 3,4-dihydro-, hydrochloride, (4R)- (9CI);(R)-chroman-4-amine hydrochloride;(4R)-3,4-DIHYDRO-2H-1-BENZOPYRAN-4-AMINE HCl;(R)-4-Aminochromane Hydrochloride
• CAS NO: 730980-59-3
• Molecular Formula: C₉H₁₁NO*ClH
• Molecular Weight: 185.65
• Mol File: 730980-59-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: (R)-CHROMAN-4-YLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-CHROMAN-4-YLAMINE HYDROCHLORIDE(730980-59-3)
• EPA Substance Registry System: (R)-CHROMAN-4-YLAMINE HYDROCHLORIDE(730980-59-3)

Safety Data

• Hazardous Substances Data: 730980-59-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(R)-CHROMAN-4-YLAMINE HYDROCHLORIDE is used as a key intermediate in the synthesis of inhibitors of apoptosis proteins (IAP) antagonists. These antagonists are designed to target and inhibit the activity of IAPs, which are proteins that play a crucial role in regulating cell survival and apoptosis (programmed cell death). By inhibiting IAPs, these antagonists can promote apoptosis in cancer cells, making them potential therapeutic agents for the treatment of various types of cancer.
(R)-CHROMAN-4-YLAMINE HYDROCHLORIDE is used as a building block for the development of novel tricyclic compounds. These compounds are also designed to act as IAP antagonists, offering an alternative approach to targeting IAPs in cancer treatment. The unique chemical structure of these tricyclic compounds may provide improved potency, selectivity, or pharmacokinetic properties compared to existing IAP inhibitors.
Used in Chemical Research:
In addition to its applications in the pharmaceutical industry, (R)-CHROMAN-4-YLAMINE HYDROCHLORIDE may also be utilized in chemical research for the development of new compounds with potential applications in various fields. Its unique structure and reactivity make it a valuable starting material for the synthesis of a wide range of organic compounds, including those with potential biological, pharmaceutical, or materials science applications.

Upstream product

• 730980-58-2 2-methoxy-N-((R)-3,4-dihydro-2H-chromen-4-yl)acetamide 

Downstream Products

• 1266230-97-0 tert-butyl [(1S)-2-({(1S)-1-cyclohexyl-2-[(3S,8aR)-3-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]-7,7-difluorohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxoethyl}amino)-1-methyl-2-oxoethyl]methylcarbamate 
• 1266230-93-6 tert-butyl [(1S)-2-({(1S)-1-cyclohexyl-2-[(3S,8aR)-3-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxoethyl}amino)-1-methyl-2-oxoethyl]ethylcarbamate 
• 1266230-62-9 tert-butyl {(1S)-1-cyclohexyl-2-[(3S,8aR)-3-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]-7,7-dimethoxyhexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxoethyl}carbamate 
• 1266230-60-7 tert-butyl [(1S)-2-({(1S)-1-cyclohexyl-2-[(3S,7R,8aR)-3-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]-7-hydroxy-7-methylhexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxoethyl}amino)-1-methyl-2-oxoethyl]methylcarbamate 
• 1266230-55-0 tert-butyl [(1S)-2-({(1S)-1-cyclohexyl-2-[(3S,7R,8aR)-3-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]-7-hydroxyhexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxoethyl}amino)-1-methyl-2-oxoethyl]methylcarbamate 
• 1266230-01-6 tert-butyl [(1S)-2-({(1S)-1-cyclohexyl-2-[(3S,8aR)-3-[(4R)-3,4-dihydro-2H-cromen-4-ylcarbamoyl] hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxoethyl}amino)-1-methyl-2-oxoethyl]methylcarbamate 

Relevant articles and documents

INHIBITOR OF APOPTOSIS (IAP) PROTEIN ANTAGONISTS

Provided herein are compounds that modulate the activity of melanoma inhibitor of apoptosis (ML-IAP) protein, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

Amino-1,3,5-triazines N-substituted with chiral bicyclic radicals, process for their preparation, compositions thereof, and their use as herbicides and plant growth regulators

Amino-1,3,5-triazines N-substituted with chiral bicyclic radicals, process for their preparation, compositions thereof, and their use as herbicides and plant growth regulators. The invention relates to an optically active compound of formula (I) or a salt thereof: wherein the various symbols are as defined in the description, to proceses for their preparation, to compositions thereof, and to their use as herbicides or plant growth regulators. The invention also relates to novel intermediates of formula (III), (V) and (XIII) as defined in the description.