- Difunctionalization of Alkynones by Base-Mediated Reaction with α,α-Dithioketones
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A novel 1,2-difunctionalization of alkynones via an umpolung strategy for the synthesis of tetrasubstituted olefins has been developed. This procedure is realized by a formal C-C σ-bond cleavage reaction of cyclic α,α-dithioketones and subsequent deprotection. Notable features of this approach include excellent yields, mild reaction conditions, a broad substrate scope, and operational simplicity.
- Yang, Yajie,Cheng, Lu,Wang, Mengdan,Yin, Liqiang,Feng, Ye,Wang, Chengyu,Li, Yanzhong
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supporting information
p. 5339 - 5343
(2021/07/26)
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- Weinreb amide based building blocks for convenient access to 1,1-diarylethenes and isocombretastatin analogues
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A successful strategy based on the synthetic equivalent containing Weinreb amide functionality for the convenient access to 1,1-diarylethenes in general and for the isocombretastatin analogues in particular has been developed from the commercially available glyoxalic acid. The convenience with which the structural variations can be made in assembling the aryl residues shows generality associated with the developed strategy. The intermediates also provide access to 1,2,2-triarylethanones, represented by the synthesis of advanced intermediate of tamoxifen.
- Balasubramaniam, Sivaraman,Kommidi, Harikrishna,Aidhen, Indrapal Singh
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supporting information; experimental part
p. 2683 - 2686
(2011/06/19)
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