- One-pot two-step synthesis of 4-vinylphenols from 4-hydroxy substituted benzaldehydes under microwave irradiation: a new perspective on the classical Knoevenagel-Doebner reaction
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The classical Knoevenagel-Doebner reaction is reinvestigated wherein the direct synthesis of substituted 4-vinylphenols instead of the expected 4-hydroxycinnamic acids is described. The condensation reaction is performed on 4-hydroxy substituted benzaldehydes and malonic acid with a mixture of acetic acid-piperidine as condensing agent under focused microwave irradiation. The occurrence of simultaneous condensation-double decarboxylation without the use of any decarboxylating agent is a new finding, the reaction being facilitated solely by the hydroxy substituent and microwave irradiation effect.
- Sinha, Arun K.,Sharma, Anuj,Joshi, Bhupendra P.
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p. 960 - 965
(2007/10/03)
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- Dichloromethane activation. Direct methylenation of ketones and aldehydes with CH2Cl2 promoted by Mg/TiCl4/THF
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(Chemical Equation Presented) This Mg-TiCl4-promoted CH 2-transfer reaction of CH2Cl2 represents an extremely simple, practical, and efficient methylenation of a variety of ketones and aldehydes, especially in enolizable or sterically hindered ketones such as 2,2-dimethylcyclohexanone, camphor, and fenchone.
- Yan, Tu-Hsin,Tsai, Chia-Chung,Chien, Ching-Ting,Cho, Chia-Ching,Huang, Pei-Chen
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p. 4961 - 4963
(2007/10/03)
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- Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof
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The present invention provides compounds having the structure: STR1 wherein R1 represents alkoxy or aralkoxy, R2 represents hydrogen, alkoxy, aralkoxy, alkyl, aralkyl, or R1 and R2 taken together represent the g
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