731852-88-3 Usage
Chemical structure
1-CBZ-6-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-1,2,3,4-TETRAHYDROPYRIDINE is a chemical compound that features a tetrahydropyridine ring with a boron-containing tetrahydrodioxaborolane group attached to it.
Protecting group
The compound has a carbobenzyloxy (CBZ) protecting group attached to the tetrahydropyridine ring, which serves to protect the molecule from unwanted reactions during synthesis and purification processes.
Boron-containing compound
The presence of a boron atom in the tetrahydrodioxaborolane group makes this compound a boron-containing molecule, which is significant for its potential applications in medicinal chemistry.
Biological activities
Boron-containing compounds have been found to exhibit various biological activities, such as anticancer, antiviral, and enzyme inhibition properties. This suggests that 1-CBZ-6-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-1,2,3,4-TETRAHYDROPYRIDINE may have potential applications in the development of new drugs and therapies.
Unique structure
The specific arrangement of the tetrahydropyridine ring, the boron-containing tetrahydrodioxaborolane group, and the CBZ protecting group makes this compound a potentially interesting molecule for further study and development in the field of pharmaceutical research and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 731852-88-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,3,1,8,5 and 2 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 731852-88:
(8*7)+(7*3)+(6*1)+(5*8)+(4*5)+(3*2)+(2*8)+(1*8)=173
173 % 10 = 3
So 731852-88-3 is a valid CAS Registry Number.
InChI:InChI=1/C19H26BNO4/c1-18(2)19(3,4)25-20(24-18)16-12-8-9-13-21(16)17(22)23-14-15-10-6-5-7-11-15/h5-7,10-12H,8-9,13-14H2,1-4H3
731852-88-3Relevant articles and documents
Preparation and Suzuki-Miyaura coupling reactions of tetrahydropyridine-2- boronic acid pinacol esters
Occhiato, Ernesto G.,Lo Galbo, Fabrizio,Guarna, Antonio
, p. 7324 - 7330 (2007/10/03)
A study on the conversion of lactam-derived vinyl triflates and phosphates into the corresponding vinyl boronates was carried out. While δ-valerolactam-derived vinyl triflates were successfully converted into 1,4,5,6-tetrahydropyridine-2-boronic acid pinacol ester derivatives by Pd-catalyzed coupling reaction with both bis(pinacolato)diboron and pinacolborane, pyrrolidinone and ε-caprolactam derivatives either did not react or were readily reduced. The δ-valerolactam-derived vinyl boronates are thermally stable compounds that efficiently coupled, under Pd catalysis, with structurally diverse aryl and heteroaryl bromides and triflates, vinyl iodides and bromides, and aromatic acid chlorides, to give the corresponding 2-substituted piperidines in good to excellent yields. The number of electrophiles that can virtually be coupled with these new boronic esters makes them very useful reagents for the synthesis of N-heterocyclic compounds.
A lactam-derived vinyl boronate as a stable and crystalline reagent for the synthesis of 2-substituted piperidines by Pd-catalyzed coupling reactions
Ferrali, Alessandro,Guarna, Antonio,Lo Galbo, Fabrizio,Occhiato, Ernesto G.
, p. 5271 - 5274 (2007/10/03)
A δ-valerolactam-derived vinyl triflate has been converted into the corresponding vinyl boronate by Pd-catalyzed coupling with bis(pinacolato) diboron, which results in an umpolung. This boronate efficiently couples under Pd catalysis with aryl and hetero
