- AZOLE-SUBSTITUTED PYRIDINE COMPOUND
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The present invention provides a compound represented by formula [I'| shown below or a pharmaceutically acceptable salt thereof that has an inhibitory effect on 20-HETE producing enzyme, wherein the structure represented by formula [III] shown below represents any of the structures represented by formula group [IV] shown below, wherein R1 represents a hydrogen atom, a fluorine atom, methyl, etc.; R2, R3, and R4 each independently represent a hydrogen atom, a fluorine atom, or methyl; W represents a single bond, C1-3alkanediyl, or the formula -O-CH2CH2-; and ring A represents (a) substituted C4-6cycloalkyl, (b) substituted 4- to 6-membered saturated nitrogen-containing heterocyclyl, (c) substituted phenyl, (d) substituted pyridyl, (e) substituted 2,3-dihydrobenzofuran, (f) 4- to 6-membered saturated oxygen-containing heterocyclyl, etc.
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Paragraph 0647; 0648; 0649
(2019/01/08)
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- SUBSTITUTED 5-CYANOINDOLE COMPOUNDS AND USES THEREOF
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A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for the treatment of lysine (K)-specific demethylase 1A (LSD1) - mediated diseases or disorders, Formula (I), wherein R1, R2, R3, R4, and R5 are as defined herein.
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Paragraph 00321
(2019/01/10)
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- BRUTON'S TYROSINE KINASE INHIBITORS
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Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. (Formula I)
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Page/Page column 1107; 108
(2014/05/24)
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- Daucus carota mediated-reduction of cyclic 3-oxo-amines
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Carrots (Daucus carota) were used to reduce cyclic amino-ketones in high yields and enantiomeric excesses. This cheap, eco-compatible, and efficient reducing reagent allows the easy access to precursors of biologically active products.
- Lacheretz, Romain,Pardo, Domingo Gomez,Cossy, Janine
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supporting information; experimental part
p. 1245 - 1248
(2009/08/08)
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- Syntheses of ureas
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The present invention provides intermediates, synthetic methods and novel urea compositions of matter.
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Page/Page column 15
(2010/02/15)
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- Piperazine- and piperidine-derivatives as melanocortin receptor agonists
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The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction.
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Page/Page column 41
(2010/02/06)
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- Sulfamylbenzoic acids
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Certain mono- and disubstituted-5-sulfamylbenzoic acids, many of which are novel, and their use in lowering blood lipid levels in mammals.
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