- A molybdenum(VI) complex as an efficient catalyst for the synthesis of dihydropyridines
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An efficient synthesis of various substituted Hantzsch-1,4-dihydropyridines and hexahydroquinolines, using a molybdenum(VI) complex as homogenous catalyst, from aldehydes, β-keto esters or cyclohexadiones and ammonium acetate in molten tetrabutyl ammonium
- Khabazzadeh, Hojatollah,Sheikhshoaie, Iran,Saeid-Nia, Samira
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experimental part
p. 125 - 127
(2011/12/04)
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- Synthesis of 1,4-dihydropyridines and their hypotensive activity
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1,4-Dihydropyridines (1-35) have been synthesised by treating different aldehydes with dicarbonyl compounds and ammonium hydroxide and are found to possess hypotensive activity.
- Shinde, D. B.,Shinde, N. D.,Shingare, M. S.,Dubey, M. P.,Patnaik, G. K.
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p. 920 - 922
(2007/10/03)
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- 1,4-Dihydropyridine antagonist activities at the calcium channel: A quantitative structure-activity relationship approach
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The effect of 46 1,4-dihydropyridine-type calcium channel antagonists on the tonic contractile response of longitudinal muscle strips of guinea pig ileum was determined. 2,6-Dimethyl-3,5-dicarbomethoxy-4-phenyl-1,4-dihydropyridine (13) and 13 ortho-, 15 meta-, and seven para-monosubstituted and 10 polysubstituted aromatic derivatives of 13 were studied. The pharmacological activities of the monosubstituted derivatives were best correlated by eq 10, log 1/C = 0.68π + 2.50σ(m) - 0.47L(meta) - 3.40B1(para) + 11.31, which had a correlation coefficient of 0.89. The full data set was best correlated by eq 11, log 1/C = 0.62π + 1.96σ(m) - 0.44L(meta) - 3.26B1(para) - 1.51L(meta) + 14.23, which had a correlation coefficient of 0.90. Equations of similar form but involving an ortho steric term were found to correlate the radioligand binding data for this class of compounds.
- Coburn,Wierzba,Suto,Solo,Triggle,Triggle
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p. 2103 - 2107
(2007/10/02)
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