- Synthesis, evaluation of pharmacological activity, and molecular docking of 1,4-dihydropyridines as calcium antagonists
-
1,4-Dihydropyridine (DHP) is an important class of calcium antagonist. It inhibits the influx of extracellular Ca2+ through L-type voltage-dependent calcium channels. Two series of nifedipine analogues were synthesized and evaluated as calcium
- Shaldam, Moataz Ahmed,El-Hamamsy, Mervat Hamed,Saleh, Dalia Osama,El-Moselhyb, Tarek Fathy
-
p. 297 - 304
(2016/05/19)
-
- Magnetic Fe3O4 nanoparticles: Efficient and recoverable nanocatalyst for the synthesis of polyhydroquinolines and Hantzsch 1,4-dihydropyridines under solvent-free conditions
-
A green approach for efficient and rapid synthesis of biologically active substituted Hantzsch 1,4-dihydropyridine and polyhydroquinoline derivatives using magnetic Fe3O4 nanoparticles (Fe3O 4 MNPs) as a recyclable catalyst under solvent-free conditions was reported. The catalyst was characterized by FT-IR, XRD, and TEM analysis. Compared to the classical reactions, this method consistently has the advantages of short reaction times, little catalyst loading, high yields, easy magnetic separation and reusability of the catalyst.
- Nasr-Esfahani, Masoud,Hoseini, S. Jafar,Montazerozohori, Morteza,Mehrabi, Rasool,Nasrabadi, Hasan
-
-
- Ultrasound-accelerated synthesis of 1,4-dihydropyridines in an ionic liquid
-
Hantzsch 1,4-dihydropyridine compounds were synthesized efficiently in high yields at room temperature within short times in 1,1,3,3-N,N,N′,N′- tetramethylguanidinium trifluoroacetate as ionic liquid using ultrasound irradiation. The ionic liquid can be recovered conveniently and reused efficiently. Springer-Verlag 2006.
- Shaabani, Ahmad,Rezayan, Ali H.,Rahmati, Abbas,Sharifi, Masoumeh
-
-
- Synthesis of Hantzsch 1,4-dihydropyridines under solvent-free condition using Zn[(L)proline]2 as Lewis acid catalyst
-
The present short communication describes a Lewis acid (Zn[(L)proline] 2) catalysed one pot synthesis of Hantzsch 1,4-dihydropyridine (DHP) derivatives under solvent-free condition by conventional heating and microwave irradiation. The Lewis acid catalyst Zn[(L)proline]2 used in this reaction afford moderate to good yield. The catalyst is reusable upto five cycles without appreciable loss of its catalytic activity.
- Sivamurugan,Kumar, R. Suresh,Palanichamy,Murugesan
-
p. 969 - 974
(2007/10/03)
-
- Enantiospecific synthesis of dihydropyridines from chiral enamines
-
A new asymmetric synthesis of dihydropyridines is described. This methodology is based on the use of chiral aminoalcohols to produce enamines, which were used in the synthesis of enantiopure 2-alkyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridines. The known stereochemistry of these compounds was exploited to obtain 1,4-dihydropyridines with controlled configuration at C-4.
- Caballero, Esther,Puebla, Pilar,Sanchez, Mar,Medarde, Manuel,Moran Del Prado, Lourdes,San Feliciano, Arturo
-
p. 1985 - 1994
(2007/10/03)
-
- Research on the synthesis of 1,4-dihydropyridines under microwave
-
Four 1,4-dihydropyridines were synthesized through the condensation of methyl 3-aminocrotonate with methyl acetoacetate-benzaldehydes under microwave without using solvents.
- Zhang,Shen,Pan,Lu,Chen
-
p. 857 - 862
(2007/10/02)
-
- Synthesis of 1,4-dihydropyridines and their hypotensive activity
-
1,4-Dihydropyridines (1-35) have been synthesised by treating different aldehydes with dicarbonyl compounds and ammonium hydroxide and are found to possess hypotensive activity.
- Shinde, D. B.,Shinde, N. D.,Shingare, M. S.,Dubey, M. P.,Patnaik, G. K.
-
p. 920 - 922
(2007/10/03)
-
- 1,4-Dihydropyridine antagonist activities at the calcium channel: A quantitative structure-activity relationship approach
-
The effect of 46 1,4-dihydropyridine-type calcium channel antagonists on the tonic contractile response of longitudinal muscle strips of guinea pig ileum was determined. 2,6-Dimethyl-3,5-dicarbomethoxy-4-phenyl-1,4-dihydropyridine (13) and 13 ortho-, 15 meta-, and seven para-monosubstituted and 10 polysubstituted aromatic derivatives of 13 were studied. The pharmacological activities of the monosubstituted derivatives were best correlated by eq 10, log 1/C = 0.68π + 2.50σ(m) - 0.47L(meta) - 3.40B1(para) + 11.31, which had a correlation coefficient of 0.89. The full data set was best correlated by eq 11, log 1/C = 0.62π + 1.96σ(m) - 0.44L(meta) - 3.26B1(para) - 1.51L(meta) + 14.23, which had a correlation coefficient of 0.90. Equations of similar form but involving an ortho steric term were found to correlate the radioligand binding data for this class of compounds.
- Coburn,Wierzba,Suto,Solo,Triggle,Triggle
-
p. 2103 - 2107
(2007/10/02)
-