- 2,4-Dinitroimidazole: Microwave Assisted Synthesis and Use in Synthesis of 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazole Analogues with Antimycobacterial Activity
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2,4-Dinitroimidazole (2,4-DNI), an important starting material for nitroimidazooxazole and nitroimidazooxazine types of antitubercular agents was synthesized by rearrangement of 1,4-dinitroimidazole (1,4-DNI) under microwave irradiation. Various new nitro
- Bhaumik, Kankan,Akamanchi
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- Potential Radiosensitizing Agents. 2. Synthesis and Biological Activity of Derivatives of Dinitroimidazole with Oxiranes
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A series of 1-substituted 2,4-dinitroimidazole analogues have been synthesized and tested for their radiosensitizing ability for selectively sensitizing hypoxic mammalian cells to the lethal effect of radiation.The reaction of 2,4(5)-dinitroimidazole (1) with a variety of oxiranes upon heating in absolute ethanol yielded the expected 1-substituted 2,4-dinitroimidazoles (2) and also resulted in the formation of a novel class of isomeric nitroimidazooxazoles (3 and 4) by intramolecular cyclization.The results of radiosensitizing activity of these agents against hypoxic Chinese hamster cells (V-79) indicated that 2,4-dinitroimidazoles were better sensitizers than the nitroimidazooxazoles, suggesting the necessity of the 2-nitro function in the molecule.The 1-(2-hydroxy-3-methoxypropyl)-2,4-dinitroimidazole (2d) was found to be the most effective radiosensitizer of this series.
- Sehgal, Raj K.,Webb, Matthew W.,Agrawal, Krishna C.
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p. 601 - 604
(2007/10/02)
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