73447-08-2Relevant academic research and scientific papers
Annulation of Conjugated Azine-Imine with a Sulfoxonium Ylide in a Noncarbenoid Route to Synthesize Multisubstituted Imidazole-Fused Heterocycles
Guchhait, Sankar K.,Saini, Meenu,Khivsara, Viren J.,Giri, Santosh K.
, p. 5380 - 5387 (2021/05/05)
A new [4+1]-annulation of in situ generated heterocyclic azine-aldimines with β-keto sulfoxonium ylides has been developed. The reaction constructs N-fused imidazole rings. In the reaction, the ylides play a dual-functional role of a nucleophilic 1,1-dipo
A novel approach towards design, synthesis and evaluation of some Schiff base analogues of 2-aminopyridine and 2-aminobezothiazole against hepatocellular carcinoma
Chacko, Shinu,Samanta, Subir
, p. 162 - 176 (2017/02/26)
Hepatocellular carcinoma is the most common primary malignancy of the liver with poor prognosis. In this study novel, Schiff's bases of 2-aminopyridine (SSSC-26 to 31) and 2-aminobenzothiazole (SSSC-32 to 37) were designed, synthesised and evaluated for antioxidant potential using DPPH method, and anti-hepatocellular carcinoma property using diethylnitrosamine (DEN) induced hepatocellular carcinoma rat model. The in-silico pharmacokinetic, rule of five and toxicity studies reveals that all the leads have an excellent intrinsic quality and sufficient structural features necessary for an oral activity. Molecular docking studies of all compounds into the ligand binding pocket of checkpoint kinase1 and vascular endothelial growth factor receptor-2 was also performed using Schrodinger software suite v8.5, and which have shown good Glide scores. Further compounds were synthesised based on the docking score and ADMET profile. The 1,1-diphenyl-2-picrylhydrazil (DPPH) scavenging study was carried out, and results showed that SSSC-29 (IC50-63.60) and SSSC-33 (IC50-60.32) were having good anti-oxidant potential in comparison with ascorbic acid (IC50-55.27). SSSC-33 further evaluated for anti-cancer potential against diethylnitrosamine (200 mg/kg bw) induced hepatocellular carcinoma in rats. The biochemical, histopathological and morphological data showed that SSSC-33 can reverse the changes occurred in the cancerous liver significantly. All these findings suggested that SSSC-33-((benzo[d]thiazol-2-ylimino) methyl)phenol) could be a potential compound in combating the oxidative damage of hepatic cells occurred due to the development of hepatocellular carcinoma induced by a chemical carcinogen, DEN.
Theoretical vibrational mode analysis of schiff bases using semi empirical methods-II
Agnihotri, Sonal,Singh, Bhoop,Burman, Kiran,Arora, Kishor
experimental part, p. 2089 - 2091 (2012/02/14)
Two new Schiff bases viz., 2N-[(4-chlorobenzalidene)aminopyridine] and 2N-[(4-hydroxybenzalidene)aminopyridine] were synthesized using 4-chlorobenzaldehyde, 4-hydroxybenzaldehyde and 2-amino pyridine in separate procedures. Their IR spectra was obtained e
Physicochemical investigations of Th(IV) and UO2(VI) complexes with new schiff bases along with their toxic effects
Agnihotri, Sonal,Arora, Kishor
body text, p. 1045 - 1054 (2011/12/14)
Schiff bases were obtained using p-trimethoxy benzaldehyde, p-hydroxyl benzaldehyde and 2-amino pyridine to prepare new complexes of thorium(IV) and dioxouranium(VI) metals by various anions. The synthesized ligands and complexes were analytically studied
