- Improved resolution of (+)-cis-2'-hydroxy-5,9-dimethyl-6,7-benzomorphan and preparation of racemic, (+)-, and (-)-cis-2-methylcyclopropyl-2'-hydroxy- 5,9-dimethyl-6,7-benzomorphan (cyclazocine)
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We report novel procedures for the efficient resolution of (±)-cis-2'- hydroxy-5,9-dimethyl-6,7-benzomorphan via the (-)-N-acetyl-L-glutamate and (+)-α-bromocamphor-π-sulfonate salts, the direct N-substitution of the (+)- α-bromocamphor-π-sulfonate salts, and the use of these methods for the synthesis of racemic, (+)-, and (-)-cyclazocine.
- Boulanger, William A.
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p. 2201 - 2210
(2007/10/03)
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