- A Preparation method of Taurine surfactant derived from natural oil
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The present invention relates to a process for preparing taurine based surfactants from natural oils. The present invention relates to a method for preparing a taurine surfactant, and more particularly, to a method for preparing a taurine surfactant by direct reaction of taurine with natural oil without further processing. In addition, the taurine-based surfactant produced by the method may be used as an efficient raw material, has excellent physical properties and detergency, and has excellent cleaning power when the detergent composition and detergent are prepared.
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Paragraph 0098-0100; 0102
(2021/05/11)
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- Synthetic method and medicinal preparation of sodium taurocholate
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The method comprises the following steps: S10, dissolving taurine and a base in water for salt formation reaction, drying the generated salt after the reaction is ended, and obtaining taurine sodium. S20, the taurine sodium and cholic acid are subjected to condensation reaction under 2 - ethoxy -1 - ethoxycarbonyl -1 and 2 - 80 - 120 °C dihydroquinoline, and a product solution containing sodium taurocholate is obtained. S30, sodium taurocholate in the product solution is separated and purified to obtain the sodium taurocholate product. To the method, taurine and a base are subjected to salt formation reaction to obtain sodium taurocholate, and condensation reaction is carried out, so that an existing 'one-pot' is changed into a two-step method. In addition, the synthetic method provided by the invention is simple to operate and low in cost.
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Paragraph 0068-0069; 0072-0073; 0076-0077; 0080-0081
(2021/11/03)
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- Preparation method of sodium taurate
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The invention provides a preparation method of sodium taurate. The preparation method comprises the following steps: dissolving sodium hydroxyethyl sulfonate and a raw material sodium taurate into a guanidyl-containing ionic liquid, performing a reaction to obtain an ionic liquid solution containing a mixed product of sodium ditaurate and sodium tritaurate, introducing liquid ammonia into the ionic liquid solution of the mixed product, performing a reaction to obtain an ionic liquid solution of the product sodium taurate, adding the ionic liquid solution of the product sodium taurate into an alcohol solvent for solvating out, and separating out the obtained precipitated solid to obtain the product sodium taurate. The sodium taurate preparation method is high in product yield, good in purity, high in raw material utilization rate, simple and convenient in process and mild in reaction condition, the production efficiency of sodium taurate can be greatly improved, and the production costis reduced, so that the sodium taurate preparation method has a very good industrial application prospect.
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Paragraph 0093-0095
(2020/05/30)
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- Method for preparing taurine
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The invention provides a method for preparing taurine. The method comprises the following steps: carrying out an addition reaction on ethylene oxide and sodium hydrogen sulfite in the presence of a heterogeneous catalyst so as to obtain sodium hydroxyethyl sulfonate at high selectivity; carrying out an ammonolysis reaction on the synthesized sodium hydroxyethyl sulfonate under catalysis of a homogeneous catalyst; and neutralizing, crystallizing, separating and the like, thereby obtaining the finished taurine. Compared with the traditional production process, the process disclosed by the invention has the advantages that by-products in the addition reaction process can be obviously reduced, the temperature and pressure of the ammonolysis reaction are reduced, the reaction time is shortened,and industrial production is easily realized.
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Paragraph 0046; 0048; 0049; 0050; 0052
(2019/04/06)
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- A PROCESS FOR PRODUCING TAURINE
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The present application provides a process for preducing taurine, comprising the steps as follows: (a) mixing isethionic acid with taurine salt solution until the system pH reaches a certain value in a range from 5.0 to 9.5; (b) separating liquid phase and solid phase of the system; wherein said solid phase is the crude product of taurine, and said liquid phase is isethionate solution; (c) reacting ammonia solution with said liquid phase obtained from step (b) to obtain taurine salt solution. It uses isethionic acid to adjust the pH of the taurine salt solution, avoiding the problem causing by using sulphate acid to adjust the pH in the traditional process. By the recycling use of the cations in taurine salts, a new raw material or reagent does not need to be added which is benefit to reducing the use of dangerous chemical materials, simplifying the production process greatly, improving the utilization rate of raw materials, increasing the yield of the product and decreasing production cost significantly.
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Paragraph 0028
(2018/08/09)
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- High-yield circular production method of taurine
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The high-yield circular production method of taurine includes the following steps: S1, ethylene oxide reacts with sodium bisulfite solution to generate sodium hydroxyethyl sulfonate; S2, sodium hydroxyethyl sulfonate obtained in S1 is subjected to ammonolysis reaction in ammonia, and ammonia gas is recycled through flash evaporation upon completion of the reaction; S3, a reaction solution obtained after flash evaporation in S2 is sent to pass through an acidic cation exchange resin column, a material liquid containing taurine is collected, the inactivated resin column is subjected to regeneration with sulfur dioxide or carbon dioxide aqueous solution, and an eluent acquired during regeneration can be recycled directly or recycled after treated by sulfur dioxide; S4, the material liquid collected in S3 is subjected to post treatment to acquire taurine.
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Page/Page column 8
(2018/09/30)
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- PEPTIDIC LINKERS AND CRYPTOPHYCIN CONJUGATES, USEFUL IN THERAPY, AND THEIR PREPARATION
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The present disclosure relates to compounds of formula (I): RCG1-L-P (I) wherein RCG1 represents a reactive chemical group being reactive towards a chemical group present on a polypeptide such as an antibody; P represents H, OH or an activated O; and L represents a specific linker. The disclosure also relates to cryptophycin payloads, as well as to cryptophycin conjugates, to compositions containing them and to their therapeutic use, especially as anticancer agents. The disclosure also relates to the process for preparing these conjugates.
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Page/Page column 239; 240
(2018/12/02)
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- Method for preparing taurine and co-producing bicarbonate
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The invention discloses a method for preparing taurine and co-producing bicarbonate. The method comprises the step of leading carbon dioxide gas or adding a carbon dioxide water solution to an amino ethyl sulfonate water solution of alkali metal or ammonium to regulate a pH value so as to obtain the taurine and the bicarbonate. The method can replace an existing taurine preparation method of using sulfuric acid or sulfur dioxide to regulate the pH value, meanwhile can treat boiler exhaust gas, turns the carbon dioxide in the exhaust gas into wealth, co-produces the bicarbonate and is a safe, environmentally-friendly and energy-saving method for producing the taurine and co-producing the bicarbonate.
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Paragraph 0043; 0044
(2016/10/08)
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- Method of fully recycling mother liquid to produce taurine
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The invention discloses a method of fully recycling mother liquid to produce taurine.The method specifically includes: utilizing ethylene oxide and sodium hydrogen sulfite to prepare 2-hydroxy ethyl sodium sulfonate; preparing sodium taurate through high temperature high pressure and concentration; removing impurities through 2-stage neutralizing to obtain a taurine crude product; subjecting the mother liquid to press filtering and catalysis to further remove sodium sulfate, recycling to a synthesis section, combining with an ammonia solution of hydroxy ethyl sodium sulfonate, enabling a mixture to enter a synthesis tower for reaction, and controlling a proportion of hydroxy ethyl sodium sulfonate to the mother liquid to enable hydroxy ethyl sodium sulfonate which does not react completely in the mother liquid to react completely.Therefore, discharging pollution of the mother liquid is avoided completely, and total reaction yield is increased.
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Paragraph 0024; 0025
(2016/10/10)
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- Cyclic process for the production of taurine from alkali isethionate and alkali vinyl sulfonate
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The present invention discloses a cyclic process for the production of taurine from alkali isethionate and alkali vinyl sulfonate in a high overall yield of greater than 95% by continuously converting the byproducts of the ammonolysis reaction, sodium ditaurinate and sodium tritaurinate, to sodium taurinate. Pure sodium ditaurinate and sodium tritaurinate are prepared from diethanolamine and triethanolamine as starting materials, respectively, and are subjected to the ammonolysis reaction to yield a mixture of sodium taurinate, sodium ditaurinate, and sodium tritaurinate.
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Paragraph 0052; 0053
(2015/11/23)
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- Cyclic process for the production of taurine from ethylene oxide
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The present invention discloses a cyclic process for the production of taurine from ethylene oxide in a high yield of greater than 95% by continuously converting the byproducts of the ammonolysis reaction, sodium ditaurinate and sodium tritaurinate, to sodium taurinate. The cyclic process is completed by using sulfur dioxide or sulfurous acid to neutralize sodium taurinates to recover taurine and to regenerate sodium bisulfite, which is then reacted with ethylene oxide.
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Page/Page column 4
(2015/07/02)
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- TAURINE PREPARATION METHOD
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The present disclosure provides a process for producing taurine, includes: adjusting a PH value of a sodium taurate solution by a S4+ compound; introducing ethylene oxide into the sodium taurate solution to produce sodium hydroxyethyl sulfonate; separating crude taurine before or after introducing the ethylene oxide to the solution; and adding ammonia to the sodium hydroxyethyl sulfonate reaction solution to be reacted with the reaction solution to reproduce sodium taurate. The process for producing taurine of the present disclosure makes use of the balances of the sodium bases in the system, recycles the mother liquor until the sodium taurate is reproduced out of the reactions in the mother liquor, and thus is capable of allowing taurine to be synthesized and extracted. The process for producing taurine provided in the present disclosure makes full use of the material, avoids using a large amount of dangerous chemical material such as liquid caustic soda and sulfuric acid used in the traditional production process. This avoids producing a large amount of sodium sulfate solid waste, solves the problem that in the traditional production process the mother liquor needs to be concentrated many times and the discharged mother liquor causes environmental pollution, reduces the amount of vapor required for the many times concentrations of the mother liquor, improves the yield rate of the product, and reduces the production cost.
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Paragraph 0023
(2014/07/23)
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- PROCESS FOR PRODUCING TAURINE
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The present disclosure provides a process for producing taurine, includes: adjusting a PH value of a sodium taurate solution by a S4+ compound; introducing ethylene oxide into the sodium taurate solution to produce sodium hydroxyethyl sulfonate; separating crude taurine before or after introducing the ethylene oxide to the solution; and adding ammonia to the sodium hydroxyethyl sulfonate reaction solution to be reacted with the reaction solution to reproduce sodium taurate. The process for producing taurine of the present disclosure makes use of the balances of the sodium bases in the system, recycles the mother liquor until the sodium taurate is reproduced out of the reactions in the mother liquor, and thus is capable of allowing taurine to be synthesized and extracted.
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Paragraph 0041-0047
(2014/05/08)
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- ACETAMINOPHEN CONJUGATES, COMPOSITIONS AND METHODS OF USE THEREOF
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Acetaminophen conjugates are provided, which have an acetaminophen moiety covalently linked to a second moiety. The conjugates provided may have one or more advantageous properties, including increased water solubility as compared to acetaminophen, reduced toxicity profile as compared to acetaminophen and an altered pharmacokinetic profile. Formulations comprising the conjugates are also provided, as are methods of using the conjugates and kits comprising the conjugates.
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Paragraph 0136-0137
(2014/09/03)
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- Cyclic process for the production of taurine
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A method is disclosed for the production of taurine by a cyclic process of reacting ethylene oxide with sodium bisulfite and ammonium to obtain sodium taurinate. After excess ammonia is removed from the reaction mixture, sodium taurinate is neutralized with sulfur dioxide or sulfurous acid to recover taurine and to regenerate sodium bisulfate, which is then reacted with ethylene oxide.
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Page/Page column 4
(2014/02/15)
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- Process for the preparation of tauroursodesoxycholic acid
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The present invention relates to a novel method for preparing tauroursodeoxycholic acid which comprises a step of selective precipitation of the impurities present in the suspension obtained from the reaction of an aqueous solution of sodium taurinate with an acetonic solution of a mixed anhydride of ursodeoxycholic acid with an alkyl chloroformate.
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Page/Page column 3-4
(2008/12/04)
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- Preparation of 2-aminoalkanesulfonic acid
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The invention is a process for the preparation of the metal salt of 2-aminoalkanesulfonic acid which comprises contacting a 2-oxazolidinone with a water-soluble metal sulfite or a water-soluble metal hydrogen sulfite in aqueous solution under conditions such that a metal salt of 2-aminoethanesulfonic acid is prepared.
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