Exploration of the P2-P3 SAR of aldehyde cathepsin K inhibitors
The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S2 and S3 subsites with a series of carbamate derivatized norleucine aldehydes substituted at the P2 and P3 positions afforded analogs with cathepsin K IC50s between 600nM and 130pM.
Boros, Eric E.,Deaton, David N.,Hassell, Anne M.,McFadyen, Robert B.,Miller, Aaron B.,Miller, Larry R.,Paulick, Margot G.,Shewchuk, Lisa M.,Thompson, James B.,Willard Jr., Derril H.,Wright, Lois L.
p. 3425 - 3429
(2007/10/03)
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