736990-80-0

Basic information

• Product Name: 4-BROMO-2-(N-MORPHOLINO)-BENZALDEHYDE
• Synonyms: 4-BROMO-2-(N-MORPHOLINO)-BENZALDEHYDE;4-broMo-2-(Morpholin-4-yl)benzaldehyde;4-BroMo-2-Morpholinobenzaldehyde
• CAS NO: 736990-80-0
• Molecular Formula: C₁₁H₁₂BrNO₂
• Molecular Weight: 270.12
• Mol File: 736990-80-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-BROMO-2-(N-MORPHOLINO)-BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-(N-MORPHOLINO)-BENZALDEHYDE(736990-80-0)
• EPA Substance Registry System: 4-BROMO-2-(N-MORPHOLINO)-BENZALDEHYDE(736990-80-0)

Safety Data

• Hazardous Substances Data: 736990-80-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-2-(N-morpholino)-benzaldehyde is used as a key intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of a wide range of drug molecules, making it a valuable asset in the development of new medications.
Used in Organic Synthesis:
In the field of organic chemistry, 4-Bromo-2-(N-morpholino)-benzaldehyde is used as a building block for the synthesis of complex organic molecules. Its reactivity and functional groups enable chemists to create a diverse array of compounds for various applications, including research and commercial purposes.
Used in Research and Development:
4-Bromo-2-(N-morpholino)-benzaldehyde is employed as a research compound in academic and industrial laboratories. Its unique properties and reactivity make it an interesting subject for studying chemical reactions and exploring new synthetic pathways. This can lead to the discovery of novel compounds and advancements in the field of chemistry.

Upstream product

• 110-91-8 morpholine 
• 57848-46-1 4-bromo-2-fluorobenzaldehyde 

Downstream Products

• 197846-82-5 1-(3-bromophenyl)-morpholine 
• 1285505-69-2 N-[(E)-3-(4'-hydroxy-3-morpholine-4-yl-biphenyl-4-yl)-2-methyl-acryloyl]-guanidine 
• 1285506-96-8 C₁₅H₁₉BrN₄O₂ 
• 1285506-93-5 C₁₄H₁₆BrNO₃ 
• 1285507-38-1 C₁₆H₂₀BrNO₃ 

Relevant articles and documents

Catalyst-free photodecarbonylation ofortho-amino benzaldehyde

It is almost a consensus that decarbonylation of the aldehyde group (-CHO) needs to not only be mediated by transition metal catalysts, but also requires severe reaction conditions (high temperature and long reaction time). In this work, inspired by the “conformational-selectivity-based” design strategy, we broke this consensus and discovered a catalyst-free photodecarbonylation of the aldehyde group. It revealed that decarbonylation can be easily achieved with visible light irradiation by introducing a tertiary amine into theortho-position of the aldehyde group. A diverse array of tertiary amines is tolerated by our photodecarbonylation under mild conditions. Furthermore, the (QM) computations of the mechanism and the experiments on well-designed special substrates revealed that our photodecarbonylation depends on the conformational specificity of the aldehyde group and tertiary amine, and occurs through an unusual [1,4]-H shift and a subsequent [1,3]-H shift.

TRICYCLIC COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS

The present invention provides compounds of Formula (A): (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent, and methods of using the compositions and combinations to treat conditions including cancers.

Product-selectivity control by the nature of the catalyst: Lewis acid-catalyzed selective formation of ring-fused tetrahydroquinolines and tetrahydroazepines via intramolecular redox reaction

Selective synthesis of ring-fused tetrahydroquinolines and tetrahydroazepines from the same starting materials was achieved by subtle use of the oxophilic Sc(OTf)3 or carbophilic IPrAuOTf as the catalyst.