- Synthesis and characterization of diorganotin (IV) complexes with tridentate schiff base ligand pyridoxal aroylhydrazones
-
Dichlorodiorganotin (IV) R2SnCl2 (where R = Me, Bu, or Ph) on reaction with substituted hydrazones (H2L) derived from the condensation of pyridoxal hydrochloride with substituted acid hydrazides, H2pydx-inh (LI), H2pydx-th (LII), or H2pydx-nh (LIII) (pydx = pyridoxal, inh = isonicotinoyl hydrazone, th = 2-thiophene carboxyl hydrazone, nh = 1-naphthoyl hydrazone), dry benzene give pentacoordinated complexes of the type R2SnL(I-III). In the solution of isolated complexes the ligand acted in a tridentate manner (O,O,N), coordinating through a phenolic oxygen, oxygen of keto group after enolization, and nitrogen of azomethine group. The synthesized complexes were characterized by elemental analyses, molar conductance, molecular weight determination, and infrared (IR) and nuclear magnetic resonance (NMR; 1H, 13C, and 119Sn) spectral data. The ligands and their tin complexes were evaluated for antifungal and antibacterial activities, and the results indicate that they exhibit significant antimicrobial properties. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.
- Sonika, Nidhi,Malhotra, Rajesh
-
-
Read Online
- Synthesis, characterization and antimicrobial activity of copper(II) complexes with hydrazone derived from 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde
-
Pyridoxal isonicotinoyl hydrazone (HL) and its copper(II) complexes: [CuLCl(H2O)2] (1), [CuL(OAc)](H2O) (2), [CuL(OAcac)] (3), [CuL(NO3)](H2O) (4), [CuL2](H2O) (5) were synthesized and characterized. The ligand has been obtained by condensation of 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde (pyridoxal) hydrochloride with isonicotinoyl hydrazide. The characterization of the formed compounds was done by 1H NMR, 13C NMR, UV-Vis, IR and EPR spectroscopy as well by thermal studies and elemental analysis. The crystal structure of HL has been determined by single crystal X-ray diffraction studies. The microbiological effect of the ligand and all five complexes against both Gram-positive and Gram-negative strains, Staphylococcus aureus ATTC 6538, Bacillus cereus ATCC 14579, Escherichia coli W3110 and Pseudomonas aeruginosa ATCC 9027 was tested.
- Mezey, Reka-?tefana,Máthé, István,Shova, Sergiu,Grecu, Maria-Nicoleta,Ro?u, Tudor
-
-
Read Online
- Method of inhibiting fibrosis with pyridoxal benzoyl hydrazone and analogs thereof
-
Methods of inhibiting fibrosis comprising administering certain pyridoxal benzoyl hydrazones or analogs thereof are disclosed. Preferred hydrazones are pyridoxal benzoyl hydrazone, 3-hydroxyisonicotinaldehyde benzoyl hydrazone and salicylaldehyde benzoyl hydrazone. The methods are useful in treating fibrosing disorders, including dermal fibrosing disorders, fibrosis of internal organs and fibrotic conditions of the eye.
- -
-
-