73865-18-6

Basic information

• Product Name: Nardeterol
• Synonyms: Nardeterol [INN]; Som 1122; (+-)-alpha-(((3-(1-Benzimidazolyl)-1,1-dimethylpropyl)amino)methyl)-2-fluoro-4-hydroxybenzyl alcohol; Nardeterolum; Nardeterolum [INN-Latin]; UNII-70859437W3; Benzenemethanol, alpha-(((3-(1H-benzimidazol-1-yl)-1,1-dimethylpropyl)amino)methyl)-2-fluoro-4-hydroxy-; 4-(2-{[4-(1H-benzimidazol-1-yl)-2-methylbutan-2-yl]amino}-1-hydroxyethyl)-3-fluorophenol
• CAS NO: 73865-18-6
• Molecular Formula: C₂₀H₂₄FN₃O₂
• Molecular Weight: 357.4219
• Mol File: 73865-18-6.mol

Chemical Properties

• Boiling Point: 566.9°C at 760 mmHg
• Flash Point: 296.7°C
• Density: 1.23g/cm³
• Vapor Pressure: 1.08E-13mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: Nardeterol(CAS DataBase Reference)
• NIST Chemistry Reference: Nardeterol(73865-18-6)
• EPA Substance Registry System: Nardeterol(73865-18-6)

Safety Data

• Hazardous Substances Data: 73865-18-6(Hazardous Substances Data)

Relevant articles and documents

Inhalation Atomizer Comprising a Blocking Function and a Counter

This invention presents an inhalation atomizer comprising a blocking function through a locking-mechanism and a counter along with a method to discharge and atomize fluid. The apparatus is accommodated in a two part housing, wherein the two parts are mounted to be rotatable relative to each other, and can be blocked through a locking mechanism. The locking mechanism is realized mainly by two protrusions. Protrusion A is located on the outer wall of the lower unit of the inside part. Protrusion B is located on the inner wall of counter. When the inhalation atomizer is actuated each time, the counter will make a rotation with a constant angle around the lower unit of the inside part. Once the predetermined number of actuations has been achieved, Protrusion A and Protrusion B will encounter with each other and hence the counter will be prevented from further rotation. Therefore, the inhalation atomizer is blocked and stopped from further use. The number of actuations of the device can be counted by the counter. Only when sufficient force is applied to destroy the device, this locking state of the device can be overcome. The inhalation atomizer in the current invention can be blocked suitably by this locking-mechanism.

Inhaler Device for Administering Powered Pharmaceutical Compositions via Inhalation

An inhaler device for administering powdered pharmaceutical composition from capsules comprises of a base, a deck, a chamber, a mouthpiece and a cap. The deck can be latched to the base and closed off, and being connected to a push button (17) through a protrusion (22) and a sliding groove (16). The chamber is for holding the capsules and can be adjusted to be lowered into the base. The mouthpiece is latch-able to the deck. The cap covers the mouthpiece in a closed position and latches it by means of a closure element. The base, the deck, the mouthpiece are connected by means of a spindle. The cap is not connected to the rest of the device parts; instead, it is held together with the rest of the inhaler device by means of the protective shell (26) with a strip pattern (27) or a linking belt (29). Finally, there is a capsule-piercing unit with at least one piercing pin for piercing the capsule.

Aerosol suspension formulations with TG 227 ea or TG 134 a as propellant

The invention relates to pressurized gas formulations for dosage aerosols, in which a medicament is formulated suspended in TG 227 ea (1,1,1,2,3,3,3-heptafluoropropane) and/or TG 134 a (1,1,1,2-tetrafluoroethane) as a propellant, and to their use for producing a medicament. The aerosol is preferably an inhalation aerosol.

TRANSCORNEAL SYSTEM FOR DELIVERY OF A PHARMACEUTICAL AGENT

The invention relates to a transcorneal system for delivery of a pharmaceutical agent, made from a matrix material forming a baseplate (1), said baseplate (1) being connected to a number of projections (4) for penetration of the Stratum corneum of the skin, said projections (4) being made from the matrix material and comprising the agent.

TWO-PIECE METAL CAPSULE FOR ACCOMMODATING PHARMACEUTICAL PREPARATIONS FOR POWDER INHALERS

The invention relates to novel two-piece metal capsules for accommodating pharmaceutical preparations to be used in powder inhalers as well as a method for producing said capsule. The inventive capsules are particularly impermeable to steam and oxygen.

Propellant for Dosing Aerosols Comprising Packagings

The invention relates to a pharmaceutical product comprising a dosing aerosol containing a propellant, an effective quantity of adsorbent, a pharmaceutically active substance, substance formulation or substance mixture, and a packaging enclosing the adsorbent and the dosing aerosol with the pharmaceutically active substance, substance formulation or substance mixture.

Heterocyclic compounds

Compounds of the formula STR1 wherein Het is STR2 n is an integer from 1 to 4, inclusive, preferably 2 or 3, R1 is H or acyl, R2 is H, R1 O, --NHSO2 R7, --NHCOR8, --NHCONHR8, --NH--CH2 --C6 H4 --R9, --CH2 OH, --CH2 SO2 R7, --CONHR8, halogen or --CN, R3 is H, halogen, R7 or --OR7, R2 and R3 together with each other are STR3 R4 is H, --CH3 or --C2 H5, R5 and R6 are each H or --CH3, R7 is C1 -C4 alkyl, R8 is H or C1 -C4 alkyl, R9 is H, C1 -C4 alkyl or C1 -C4 alkoxy optionally interrupted by oxygen, R10 and R12 are each H, CH3, Cl or OCH3, or together methylenedioxy, X is STR4 or N, and Z is --CH2 or --CO; in the form of racemates, enantiomers, diastereoisomeric antipode pairs, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as bronchospasmolytics, spasmolytics, muscle-relaxants, antiallergics and hypotensives.