cas 7389-14-2, 5-Pyrimidinecarboxamide, 4-amino-2-methyl- | Articles data ｜lookchem

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7389-14-2

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PROCESS FOR THE PREPARATION OF PYRIMIDINE DERIVATIVES
A process for the preparation of 5-substituted 4-amino-2-methylpyrimidines of the formula (I) wherein R is CONH2 or CN, and of acid addition salts thereof, characterized in that a compound of formula H2N CH = C(R) CN (II) is reacted with acetimidic acid methyl ester or an acid addition salt thereof and that, if desired, a compound of formula (I) is transferred into an acid addition salt, and the transformation of a compound of formula (Il) wherein R is CONH2 into a compound of formula (Il) wherein R is CN by treatment with POCI3.
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Page/Page column 4

(2010/11/03)

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Chemical Properties

Boiling Point: 340.6°Cat760mmHg
Flash Point:159.8°C
Density: 1.344g/cm³
Vapor Pressure: 8.5E-05mmHg at 25°C
PSA: 94.89000
LogP: 0.74760

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