- ISPH INHIBITORS, AND METHODS OF MAKING AND USING SAME
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In one aspect, the invention provides novel compounds useful for treating bacterial infections, such as but not limited to Gram-negative bacterial infections. In another aspect, the invention provides novel compounds useful for activating γδ T cell respon
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Page/Page column 30; 34-35
(2021/02/05)
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- RETRACTED ARTICLE: IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance
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Isoprenoids are vital for all organisms, in which they maintain membrane stability and support core functions such as respiration1. IspH, an enzyme in the methyl erythritol phosphate pathway of isoprenoid synthesis, is essential for Gram-negati
- Singh, Kumar Sachin,Sharma, Rishabh,Reddy, Poli Adi Narayana,Vonteddu, Prashanthi,Good, Madeline,Sundarrajan, Anjana,Choi, Hyeree,Muthumani, Kar,Kossenkov, Andrew,Goldman, Aaron R.,Tang, Hsin-Yao,Totrov, Maxim,Cassel, Joel,Murphy, Maureen E.,Somasundaram, Rajasekharan,Herlyn, Meenhard,Salvino, Joseph M.,Dotiwala, Farokh
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p. 597 - 602
(2020/12/25)
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- π-Interactions as a tool for an easy deposition of meso- tetraferrocenylporphyrin on surfaces
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A bottom-up approach was employed to prepare novel Self-Assembled Monolayers (SAMs) in which a naphthyl moiety acted as a "π-binder" for unfunctionalised meso-tetraferrocenylporphyrin (H2TFcP). Four naphthalene derivatives with an appropriate functional group were synthesized and SAMs were prepared both on gold and ITO surfaces. Mixed H 2TFcP-naphthalene films were thoroughly characterized using UV-Vis, XPS and electrochemical techniques. In particular, angle-dependent XPS experiments revealed an almost perpendicular orientation of the porphyrin on surfaces, suggesting that an intercalation occurred among naphthalene units. A large amount of porphyrin was deposited on both the surfaces (in the order of 10-10 mol × cm-2), comparable to that afforded by more conventional covalent linkages. However, significant differences in homogeneity between SAMs on gold and ITO resulted in a diverse electrochemical behaviour. The electrochemical activity of the oxidised porphyrin was restored by prolonged exposure of the modified gold electrode (tens of seconds) to a negative potential, whereas no response was detected after the same treatment on ITO. This novel approach provides a general and versatile strategy to bind meso-substituted porphyrins on a pre-formed monolayer without the necessity for further functionalisations.
- Vecchi, Andrea,Grippo, Valentina,Floris, Barbara,Marrani, Andrea Giacomo,Conte, Valeria,Galloni, Pierluca
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supporting information
p. 3535 - 3542
(2013/11/06)
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- Intermolecular addition reaction to alkenes of acylmolybdenum complexes generated by oxidative addition of aryl or alkenyl halides with molybdenum(0) carbonyl complexes
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Acylmolybdenum species, generated by oxidative addition of aryl or alkenyl halides with molybdenum(0) carbonyl complex followed by carbon monoxide insertion, added to various kinds of alkenes intermolecularly to give simple addition products in good yields without formation of carbonylative Heck-type products. Georg Thieme Verlag Stuttgart.
- Sangu, Kenichiro,Watanabe, Toru,Takaya, Jun,Iwasawa, Nobuharu
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p. 929 - 933
(2008/02/02)
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- ortho-halogeno substituents effect in asymmetric cyclization of 4-aryl-4-pentenals using a rhodium catalyst
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Asymmetric cyclization of 4-aryl-4-pentenals by using a cationic [Rh((R)-BINAP)]ClO4 afforded (3R)-3-substituted cyclopentanones; on the other hand, the cyclization of 4-pentenals bearing ortho-halogeno phenyl groups afforded the opposite (3S)-ones.
- Fujio, Masakazu,Tanaka, Masakazu,Wu, Xiao-Ming,Funakoshi, Kazuhisa,Sakai, Kiyoshi,Suemune, Hiroshi
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p. 881 - 882
(2007/10/03)
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- THE REACTION OF O-ETHYL SUCCINIMIDE WITH ARYLLITHIUM COMPOUNDS: AN EFFICIENT METHOD FOR THE INTRODUCTION OF 3-ETHOXYCARBONYLPROPIONYL GROUP TO AROMATIC COMPOUNDS
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O-Ethyl succinimide (I) was found to be an efficient reagent for the introduction of 3-ethoxycarbonylpropionyl group (-COCH2CH2COOEt) to aromatic compounds by a single operation under mild conditions.
- Nagasaka, Tatsuo,Hamaguchi, Fumiko,Ozawa, Naganori,Kosugi, Yoshiyuki,Ohki, Sadao
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p. 291 - 293
(2007/10/02)
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