- The Selective Preparation of 1,4-Diaryl-6-methyl- and 1,6-Diaryl-4-methyl-2-(1H)pyrimidinones
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N-Phenylurea reacted with benzoylacetone derivatives (I) to give 1,4-diaryl-6-methyl-2-(1H)pyrimidinones (II) in addition to low yields of 1,6-diaryl-4-methyl-2-(1H)pyrimidinones (IV), while N-phenylthiourea afforded only 1,6-diaryl-4-methyl-2-(1H)pyrimidinethiones (III) in good yields.Further 1,6-diaryl-4-methyl-2-(1H)pyrimidinethiones (III) were succesfully converted in satisfactory yields into the corresponding 2-(1H)pyrimidinones (IV) by the treatment with methyl iodide in the presence of sodium methoxide in methanol at room temperature.
- Kashima, Choji,Katoh, Akira
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p. 913 - 915
(2007/10/02)
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- FACILE OXIDATION OF 2-OXO-1,4,6-TRISUBSTITUTED 1,2,3,6-TETRAHYDROPYRIMIDINES WITH CHLORANIL
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2-Oxo-1,4,6-trisubstituted 1,2,3,6-tetrahydropyrimidines (1a-1h) were easily oxidized with 2,3,5,6-tetrachloro-1,4-benzoquinone (chloranil) to afford the corresponding 1,4,6-trisubstituted 2(1H)-pyrimidones (2) in good yields.
- Kashima, Choji,Katoh, Akira,Yokota, Yuko,Omote, Yoshimori
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p. 285 - 286
(2007/10/02)
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