Site- and Regioselective Monoalkenylation of Pyrroles with Alkynes via Cp?CoIII Catalysis
A site-, regio-, syn-, and monoselective alkenylation of dimethylcarbamoyl-protected pyrroles proceeded using a catalytic amount of [Cp?Co(CH3CN)3](SbF6)2 and KOAc. A variety of internal alkynes with several fun
Palladium-Catalyzed Regioselective Dehydrogenative C–H/C–H Cross-Coupling of Pyrroles and Pyridine N-Oxides
The palladium-catalyzed cross-dehydrogenative coupling of N-alkylpyrroles and pyridine N-oxides gave the corresponding pyrrolylpyridine N-oxides. Cu(OAc)2·H2O as a co-catalyst with air as the terminal oxidant led to preferential coupling in the β-position, whereas AgOAc as the stoichiometric oxidant resulted in preferential coupling in the α-position. N-(Benzyloxymethyl)pyrrole derivatives were deprotected by hydrogenolysis followed by basic hydrolysis.
Liu, Shanshan,Tzschucke, C. Christoph
supporting information
p. 3509 - 3513
(2016/07/28)
Regioselective C2 oxidative olefination of indoles and pyrroles through cationic rhodium(III)-Catalyzed C-H bond activation
Be economic with your atoms! An efficient Rh-catalyzed oxidative olefination of indoles and pyrroles with broad substrate scope and tolerance is reported (see scheme). The catalytic reaction proceeds with excellent regio- and stereoselectivity. The directing group N,N-dimethylcarbamoyl was crucial for the reaction and could be removed easily. Copyright
Ruthenium-catalyzed regioselective C2 alkenylation of indoles and pyrroles via C-H bond functionalization
An efficient ruthenium-catalyzed oxidative coupling of indoles and pyrroles with various alkenes at the C2-position assisted by employing the N,N-dimethylcarbamoyl moiety as a directing group is reported. The catalytic reaction proceeds in an excellent regio- and stereoselective manner.