- Discovery of orally bioavailable cathepsin S inhibitors for the reversal of neuropathic pain
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Cathepsin S inhibitors are well-known to be an attractive target as immunological therapeutic agents. Recently, our gene expression analysis identified that cathepsin S inhibitors could also be effective for neuropathic pain. Herein, we describe the effic
- Irie, Osamu,Kosaka, Takatoshi,Ehara, Takeru,Yokokawa, Fumiaki,Kanazawa, Takanori,Hirao, Hajime,Iwasaki, Astuko,Sakaki, Junichi,Teno, Naoki,Hitomi, Yuko,Iwasaki, Genji,Fukaya, Hiroaki,Nonomura, Kazuhiko,Tanabe, Keiko,Koizumi, Shinichi,Uchiyama, Noriko,Bevan, Stuart J.,Malcangio, Marzia,Gentry, Clive,Fox, Alyson J.,Yaqoob, Mohammed,Culshaw, Andrew J.,Hallett, Allan
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supporting information; experimental part
p. 5502 - 5505
(2009/08/16)
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- 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF
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The invention relates to pyrrolo pyrimidines of formula (I), wherein Y represents -(CH2)t-O- or -(CH2)r-S-, p is 1 or 2, r is 1, 2 or 3, t is 1, 2 or 3, or Y is -(CH2)j- or -CH=CH-, j is 1 or 2; p is 1 or 2, or Y is -(CH2)f-, f is 1 or 2, p is 1, and the further radicals and symbols have the meaning as defined herein; their preparation, their use as pharmaceuticals, pharmaceutical compositions containing them, the use of such a compound for the manufacture of a pharmaceutical preparation for the treatment of neuropathic pain and to a method for the treatment of such a disease in animals, especially in humans.
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Page/Page column 76
(2010/02/08)
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