Mild and phosphine-free iron-catalyzed cross-coupling of nonactivated secondary alkyl halides with alkynyl grignard reagents
A simple protocol for iron-catalyzed cross-coupling of nonactivated secondary alkyl bromides and iodides with alkynyl Grignard reagents at room temperature has been developed. A wide range of secondary alkyl halides and terminal alkynes are tolerated to a
Cheung, Chi Wai,Ren, Peng,Hu, Xile
supporting information
p. 2566 - 2569
(2014/05/20)
Stereoselective synthesis of cyclopropanone ketals via silyl chloride promoted cyclization of β-zinciopropionates
Alkyl, allyl, and propargyl β-iodopropionates undergo a cyclopropanation by the reaction with zinc-copper couple and TBDMSCI in THF to give 1-alkoxy-, 1-allyloxy- and 1-propargyloxy-1-tert-butyldimethylsiloxycyclopropanes in moderate or good yields. β-Iodo-α-methylpropionates 2 and 6 provide trans-5 and trans-8 selectively, which β-iodobutyrates 3 and 7 furnish cis-5 and cis-8 selectively.
Yasui, Keigo,Tanaka, Shuji,Tamaru, Yoshinao
p. 6881 - 6900
(2007/10/02)
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