Synthesis of β-Cyano Ketones Promoted by a Heterogeneous Fluoride Catalyst
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Strappaveccia, Giacomo,Angelini, Tommaso,Bianchi, Luca,Santoro, Stefano,Piermatti, Oriana,Lanari, Daniela,Vaccaro, Luigi
p. 2134 - 2139
(2016/07/16)
Highly efficient Cs2CO3-catalyzed 1,4-addition of Me3SiCN to enones with water as the additive
A facile and efficient 1,4-addition of Me3SiCN to enones has been achieved with perfect regioselectivity using Cs2CO3 as catalyst. Thus, with 0.5 mol% of Cs2CO3 and 4 equivalents of H2O as the additive excellent yields (81-99%) of -cyanoketones are obtained within one to five hours. Both aromatic and aliphatic enones are found suitable substrates for this protocol. Georg Thieme Verlag Stuttgart · New York.
Yang, Jingya,Shen, Yongbin,Chen, Fu-Xue
experimental part
p. 1325 - 1333
(2010/07/02)
A catalytic enantioselective conjugate addition of cyanide to enones
The first synthetically useful catalytic enantioselective conjugate addition of cyanide to enones is described. The optimized conditions involved a Gd catalyst (5 or 10 mol %) derived from ligands 3 or 4 and a 1:1 ratio of TBSCN and 2,6-dimethylphenol. Th
Tanaka, Yuta,Kanai, Motomu,Shibasaki, Masakatsu
p. 6072 - 6073
(2008/12/20)
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