Novel High Energy Intermediate Analogues with Triazasterol-Related Structures as Inhibitors of Ergosterol Biosynthesis. Part I: Synthesis and Antifungal Activity of N-alkyl-N'-(phenethyl- and cyclohexenylethyl)guanidines and N2-Substituted 2-Imidazolinamines
A series of N-alkyl-N'-(phenethyl- and cyclohexenylethyl)guanidines and N2- and N2,4-substituted imidazolin-2-amine hydrochlorides with triazasterol-related structures was designed and synthesized as stable analogues to mimic high energy intermediates of ergosterol biosynthesis. The in vivo antifungal susceptibility tests with a standard panel of pathogenic fungi revealed moderate to strong antimycotic effects of the sixteen prepared compounds, in some cases comparable with the activity observed for itraconazole.
Goessnitzer, Edith,Malli, Roland,Schuster, Silvia,Favre, Bertrand,Ryder, Neil S.
p. 535 - 546
(2007/10/03)
More Articles about upstream products of 74387-77-2