74443-42-8

Basic information

• Product Name: 2-(2-Nitrophenoxy)ethylamine
• Synonyms: 2-(2-Nitrophenoxy)ethylamine;2-(2-Nitrophenoxy)ethanaMine
• CAS NO: 74443-42-8
• Molecular Formula: C₈H₁₀N₂O₃
• Molecular Weight: 182
• Mol File: 74443-42-8.mol

Chemical Properties

• Boiling Point: 335.763°C at 760 mmHg
• Flash Point: 156.864°C
• Appearance: /
• Density: 1.252g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 2-(2-Nitrophenoxy)ethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Nitrophenoxy)ethylamine(74443-42-8)
• EPA Substance Registry System: 2-(2-Nitrophenoxy)ethylamine(74443-42-8)

Safety Data

• Hazardous Substances Data: 74443-42-8(Hazardous Substances Data)

Usage

Uses

Used in Research and Industrial Settings:
2-(2-Nitrophenoxy)ethylamine is used as a building block for the synthesis of other organic compounds. Its unique chemical structure allows it to be a valuable component in the creation of various organic molecules, contributing to the advancement of research and development in the chemical industry.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-(2-Nitrophenoxy)ethylamine is employed as a key intermediate in the production of a wide range of organic compounds. Its versatility in reacting with other chemicals makes it an essential component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Development:
2-(2-Nitrophenoxy)ethylamine is utilized as a starting material in the development of new pharmaceuticals. Its ability to form various chemical bonds with other molecules makes it a promising candidate for the creation of novel drug candidates, potentially leading to the discovery of new treatments and therapies for various diseases and conditions.
Used in Agrochemical Production:
In the agrochemical industry, 2-(2-Nitrophenoxy)ethylamine is used as a precursor in the synthesis of various agrochemicals. Its role in the production of pesticides, herbicides, and other agricultural chemicals helps to ensure the development of effective solutions for crop protection and management.
Used in Specialty Chemicals Manufacturing:
2-(2-Nitrophenoxy)ethylamine is also employed in the manufacturing of specialty chemicals, which are used in a variety of applications such as coatings, adhesives, and other industrial products. Its unique properties and reactivity make it a valuable component in the production of these specialized materials.

InChI:InChI=1/C8H10N2O3/c9-5-6-13-8-4-2-1-3-7(8)10(11)12/h1-4H,5-6,9H2

Upstream product

• 98395-64-3 N-(2-ortho-nitrophenoxyethyl)phthalimide 
• 263410-15-7 tert-butyl (2-(2-nitrophenoxy)ethyl)carbamate 
• 88-75-5 2-hydroxynitrobenzene 

Downstream Products

• 919283-29-7 (3-chloro-4-{5-methyl-4-[2-(2-nitro-phenoxy)-ethylcarbamoyl]-isoxazol-3-yl}-phenyl)-acetic acid methyl ester 
• 128648-52-2 C₁₂H₁₅N₃O₅S 
• 111624-96-5 2-Isopropyl-5-[2-(2-nitro-phenoxy)-ethylamino]-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile 
• 120351-18-0 5-[2-(2-Amino-phenoxy)-ethylamino]-2-isopropyl-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile 

Relevant articles and documents

Identification of N-(2-Phenoxyethyl)imidazo[1,2-a]pyridine-3-carboxamides as New Antituberculosis Agents

A series of imidazo[1,2-a]pyridine carboxamides (IPAs) bearing an N-(2-phenoxyethyl) moiety was designed and synthesized as new antitubercular agents. Seven 2,6-dimethyl IPAs demonstrated excellent in vitro activity (MIC: 0.025-0.054 μg/mL) against the drug susceptive H37Rv strain and two clinically isolated multidrug-resistant Mycobacterium tuberculosisstrains. Compound 10j displayed acceptable safety and pharmacokinetic properties, opening a new direction for further development.

3,4,5-Trisubstituted isoxazoles as novel PPARδ agonists: Part 1

We report the identification of a novel series of trisubstituted isoxazoles as PPAR activators from a high-throughput screen. A series of structural optimizations led to improved efficacy and excellent functional receptor selectivity for PPARδ. The isoxazoles represent a series of agonists which display a scaffold that lies outside the typical PPAR agonist motif.

Synthesis of Methomyl Derivatives as new Photosensitive Molecular Probes

An approach to the photoaffinity labelling study between a methomyl analogue and Texas corn mitochondria has been undertaken.The synthesis of aromatic photosensitive and specific methomyl analogues which would also enable an appropriate radiolabel is pres