- A bioinspired microreactor with interfacial regulation for maximizing selectivity in a catalytic reaction
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We report a bioinspired emulsion microreactor composed of an electrical double layer to mimic the functions of cell membranes. This "artificial cell"can modulate the phase-oriented transport of reagents at the oil-liquid interface via the electrical double layer, affording a powerful tool to optimize the selectivity in a catalytic reaction. This journal is
- Han, Chenhui,Li, Xin-Hao,Waclawik, Eric R.,Xu, Haolan,Xu, Jingsan
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supporting information
p. 8059 - 8062
(2020/09/09)
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- Preparation method of organotin PVC stabilizer
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The invention discloses a preparation method of an organotin PVC stabilizer, and belongs to the technical field of synthesis of PVC stabilizers. According to the technical scheme, the preparation method of the organotin PVC stabilizer is technically characterized in that according to the preparation method, a specific synthetic route of the organotin PVC stabilizer is shown in the description. The preparation method of the organotin PVC stabilizer is simple, the cost is relatively low, and the effects of the prepared organotin PVC stabilizer surpass those of traditional lead-composite stabilizers, calcium-zinc composite stabilizers and organotin stabilizers.
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Paragraph 0024; 0027; 0028
(2017/10/09)
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- COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE
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This invention relates to novel diarylamino compounds that bind to the sigma-2 receptor, to pharmaceutical compositions comprising such compounds, and to methods for inhibiting or restoring synapse loss in neuronal cells, modulating a membrane trafficking
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Paragraph 0579-0580
(2017/08/01)
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- 3,5-trifluoromethylbenzene linkage 1H-pyrazole compound with antibacterial activity as well as preparation method and application of 3,5-trifluoromethylbenzene linkage 1H-pyrazole compound
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The invention discloses a 3,5-trifluoromethylbenzene linkage 1H-pyrazole compound with antibacterial activity as well as a preparation method and application of the 3,5-trifluoromethylbenzene linkage 1H-pyrazole compound, and belongs to the technical fiel
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Paragraph 0030; 0031
(2017/08/24)
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- Preparation method of novel organic tin compound with PVC (polyvinyl chloride) stabilizer action
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The invention discloses a preparation method of novel organic tin compound with PVC (polyvinyl chloride) stabilizer action, and belongs to the technical field of synthesis of PVC stabilizers. The preparation method is characterized that a particular synth
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Paragraph 0025; 0028-0029
(2017/09/01)
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- Preparation method of novel tachykinin antagonist with antibacterial activity
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The invention discloses a preparation method of a novel tachykinin antagonist with antibacterial activity and belongs to the technical field of synthesis of medical intermediates. The key point of the technical scheme is as follows: the formula is as show
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Paragraph 0030; 0031
(2017/08/31)
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- Organic tin PVC stabilizer and preparation method thereof
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The invention discloses an organic tin PVC stabilizer and a preparation method thereof, and belongs to the technical field of PVC stabilizer synthesis. According to the technical scheme, the structural formula of the organic tin PVC stabilizer is shown in
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Paragraph 0030; 0031
(2017/09/26)
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- Preparation method of novel organic tin PVC stabilizer
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The invention discloses a preparation method of a novel organic tin PVC stabilizer and belongs to the technical field of synthesis of PVC stabilizers. The main points of the technical scheme are as shown in the specification. The synthesis method is simpl
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Paragraph 0028; 0031; 0032
(2017/08/31)
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- 3,5-trifluoromethyl benzene-linked imidazoline compound with antibacterial activity and preparation method and application thereof
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The invention discloses a 3,5-trifluoromethyl benzene-linked imidazoline compound with an antibacterial activity and a preparation method and application thereof and belongs to the technical field of synthesis of medical intermediates. The key point of th
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Paragraph 0022; 0028; 0029
(2017/09/01)
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- FLAVONE DERIVATIVES AND THEIR PREPARATIVE METHOD AND MEDICAL USE
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Flavone derivatives, preparative method of the derivatives and use thereof as medicaments for treating diabetes. The structure of the derivatives is presented by formula 1: In the structure, R1 and R2, which are identical or not, represent hydrogen atom, halogen, cyano, hydroxyl, trifluoromethyl, thio-methyl, benzyloxy, C1-C8 linear chain or branch chain alkyl, C1-C8 linear chain or branch chain alkoxy. The pharmacological test indicates that the flavone derivatives can significantly increase the glucose consumption of Hep-G2 cell with insulin resistance activity, promote translocation of glucose transporter 4 of skeletal muscle cells (L6GLUT4myc) at different level, and significantly increase glucose intake and utilization by cells. The test proves the fact for the first time that the flavone derivatives can significantly promote translocation of glucose transporter 4 of skeletal muscle cells, and one of the mechanisms for treating diabetes is activating the cell AMPK phosphorylation and phosphorylating the downstream ACC.
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Paragraph 0028
(2013/09/12)
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- COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE
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This invention relates to novel diarylamino compounds that bind to the sigma-2 receptor, to pharmaceutical compositions comprising such compounds, and to methods for inhibiting or restoring synapse loss in neuronal cells, modulating a membrane trafficking
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Paragraph 0433
(2013/03/26)
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- Synthesis and biological activity of novel tiliroside derivants
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A series of new tiliroside derivatives were synthesized and characterized by analytical 1H NMR, 13C NMR and mass spectrometry. All of the compounds were evaluated for anti-diabetic properties in vitro using HepG2 cells. Compounds 3c, 3d, and 3i-l caused significant enhancements in glucose consumption by insulin-resistant HepG2 cells compared with control cells and cells that were exposed to metformin (an anti-diabetic drug). Moreover, compound 3l significantly activated adenosine 5′-monophosphate-activated protein kinase activity and reduced acetyl-CoA carboxylase activity. Thus, the tiliroside derivative 3l offers potential to be developed as a new approach for treating type II diabetes.
- Qin, Nan,Li, Chun-Bao,Jin, Mei-Na,Shi, Li-Huan,Duan, Hong-Quan,Niu, Wen-Yan
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scheme or table
p. 5189 - 5195
(2011/11/14)
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- Synthesis and Antimalarial Properties of 1-Imino Derivatives of 7-Chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and Related Structures
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To improve upon the activity and properties of the 3-aryl-7-chloro-3,4-dihydro-1,9(2H,10H)-acridinediones, a variety of 1-imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and primates.Among structural modifications prepared, including N10-alkyl and C2-substituted analogs, removal of the C9 oxygen, and introduction of an imino side chain at C9, the imines of the N10-H acridinediones were the most active compounds obtained.The imino derivative of7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)-acridinedione (9aa) proved to be highly active in advanced studies in primates.
- Kesten, Stephen J.,Degnan, Margaret J.,Hung, Jocelyn,McNamara, Dennis J.,Ortwine, Daniel F.,et al.
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p. 3429 - 3447
(2007/10/02)
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- Antileukemic evaluation of some Mannich bases derived from 2-arylidene-1,3-diketones
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The synthesis of a number of Mannich bases derived from some 3-phenylmethylene-2,4-pentanediones and 3-(3-phenyl-2-propenylidene)-2,4-pentanedione has been accomplished and the compounds were evaluated against P388 lymphocytic leukemia. Three of the thirt
- Dimmock,Raghavan,Logan,Bigam
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p. 248 - 254
(2007/10/02)
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