- INTRA VS INTERMOLECULAR AMIDOALKILATION OF AROMATICS
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Three tipes of intramolecular amidoalkylation reactions of aromatics, two endotrigonal and one exotrigonal (I, II, III), leading to indolone, N-acylisoquinolines, isoquinolone and benzazepinone derivatives were studied.In the presence of external aromatic nucleophiles competing intermolecular amidoalkylations were observed (1->2, 13->14).The mechanism and the synthetic limitations of the three types of cyclization is discussed.
- Ishai, D. Ben,Sataty, I.,Peled, N.,Goldshare, R.
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p. 439 - 450
(2007/10/02)
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