- CYCLIC TETRAMER COMPOUNDS AS PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) INHIBITORS FOR THE TREATMENT OF METABOLIC DISORDERS
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The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R1, R1, R1, R1, R1, R1, R1, R1, R1, X1, X2, and X3 are described herein.
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Paragraph 0720-0721; 0781-0782
(2020/06/16)
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- Synthesis and Bleaching Activity of 1,5-Disubstituted Imidazoles
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A variety of 1,5-disubstituted imidazoles and related compounds were prepared, and their bleaching activity was evaluated by using the lettuce seedling test. 5-(4-Benzyloxyphenyl)-1-ethylimidazole (13) caused clear chlorosis, while the 2- and 3-benzyloxyp
- Yamada, Naotaka,Kuwano, Eiichi,Kikuchi, Masamichi,Eto, Morifusa
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p. 1943 - 1948
(2007/10/02)
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- Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
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Novel heterocyclic derivatives of (4-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles, useful as antifungal and antibacterial agents.
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