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Chelating Cu from tumors has been verified as an effective and promising strategy for cancer therapy through antiangiogenesis. However, systematic removal Cu by injecting with Cu chelators will result unavoidable side effects, since Cu is indispensable to the body. In this work, a micelle targeting to tumors' newborn vessels based on a polypeptide was developed to co-load DOX and Probe X, which can go through an “OFF-to-ON” procedure to report the Cu+-capture events in vivo in a real-time way by giving near infrared (NIR) fluorescence and photoacoustic signal. By co-delivering antiangiogenesis and chemotherapeutic reagents, the tumor can be significantly suppressed, meanwhile with a low systematic toxicity. Hopefully, this work can offer new insights in designing sophisticated antitumor strategy.

The invention discloses an NQO (quinone oxidoreductase) response type near infrared fluorescence probe compound related to early diagnosis of tumor. The structure of the compound is represented as theformula (I), wherein R1 and R2 are the same or different, and R1 and R2 are independently selected from C1-6 linear alkyl, C1-6 linear alkyl carboxyl, sulfonyl or C1-6 linear alkyl ester; X is halogen. The primary cell confocal experiment of the compound proves that the compound has good NQO response capacity, can produce strong fluorescence easy to detect, and can be applied to early detection of tumor.

The invention discloses a having excellent light stability of the near-infrared cyanine dye preparation method and use, the dye of the formula I as shown in the structural formula, R1 Hydrogen, methyl, in any one of a carboxyl group; R2 Hydrogen, methyl, alkoxy in any one of; X- Is iodine ion, bromide ion in any one of; n=1 - 5 is any integer. The dye through chemical bonding will be blocked piperidine structure unit introduced into the cycloheptane boeki indole cyanine in the mother's body, such that the resulting dye has good light stability, in the near-infrared region with absorption and emission, and has good photosensitive, photo-thermal characteristic, so that the fabric is colored, near-infrared fluorescence imaging, the photodynamic treatment, heat treating the field have good application prospect. (by machine translation)

An aggregation-induced emission (AIE) cyanine-based fluorescent cassette with a large pseudo-Stokes shift was designed and prepared to sensitively image pH changes in live cells via through-bond energy transfer (TBET) from a tetraphenylethene (TPE) donor to a cyanine acceptor.

The photophysical properties of eight structurally diverse near-infrared cyanine dyes were investigated with respect to their structural features and potential use as light-harvesting sensitizers of dye sensitized solar cells. The absorption, emission, and lifetime characteristics of the dyes were assessed under a variety of conditions. The photophysical properties and sensitizing efficiency of three of the eight dyes, with an additional six-membered cyclic ring, were markedly different from the other five. The dyes absorbed light of wavelength within the range of 779–823 nm and emitted within the range of 832–876 nm.The dyes had fluorescence quantum yield in the range of 14–22%. The surface morphology and elemental analysis of the cyanine dye sensitized photoanodes were characterized via Field-Emission Scanning Microscopy Imaging (FESEM) and Transmission Electron Microscopy (TEM). The performance of the fabricated cyanine dye sensitized solar cells was assessed via current-voltage and electrochemical impedance spectroscopic measurements. The solar-to-electric power conversion efficiency ranged from 0.04% to 0.24%.

The present invention relates to a cyanine dye represented by [Chemical Formula 1] for labeling a biomolecule and a method for producing the same. [Chemical Formula 1] In [Chemical Formula 1], each of Y, Z, R_1, R_1andprime;, R_2, R_2andprime;, R_3, l and m is the same as defined in the specification.(AA) MarkerCOPYRIGHT KIPO 2015

Visualization of macrophages in live animals has been of great interest for a better understanding of inflammation. We developed a near infrared (NIR) probe CDnir7 that can selectively detect macrophages and visualize inflammation in vivo using the IVIS spectrum, Fluorescence Molecular Tomography (FMT) and Multi-Spectral Optoacoustic Tomography (MSOT). This journal is the Partner Organisations 2014.

A compound of structural formula (I). The values and alternative values are as defined herein. The invention also includes biosensors comprising nanoparticles functionalized with a compound of structural formula (I). Also described is a method for labeling a biomolecule using a compound of structural formula (I) and a method of detecting a target biomolecule using a compound of structural formula (I) or a biosensor of the invention.

With the emerging interest in optical in vivo imaging, there is an increasing demand of photostable near-infrared (NIR) dyes. Herein we report the rational design of an amine tricarbocyanine structure with improved photostability (CyNA) and its combinatorial derivatization to render CyNA-414 as a NIR-fluorescent dye with stronger emission intensity and higher photostability than the NIR standard IndoCyanine Green (ICG).

Compounds of the formula: STR1 wherein R is an alkyl, alkoxy, aryl, aryloxy, arylester, carboxy or ester derived from carboxy are used as liquid crystal materials in electro-optical displays. A typical embodiment is 5-butyl-2-(4-cyanophenyl)-1,3-dioxane which has a very low threshold voltage in nematic displays. On rubbed indium oxide surfaces the threshold voltage was 0.6 V using predominately the trans isomer. It was nematic over the range 32.2° C. to 34.6° C.

The synthesis of 2,5-disubstituted 1,3-dioxanes is described, their melting and clearing points and their physical properties (dielectric anisotropy, viscosity, transition enthalpies, optical birefringence) are investigated.The cyano substituted 1,3-dioxanes 5 and 7 are valuable materials for application in displays.