1-(4-Amino-phenyl)-pyrrolidin-3-yl-amine and 6-(3-amino-pyrrolidin-1-yl)- pyridin-3-yl-amine derivatives as melanin-concentrating hormone receptor-1 antagonists
Derivatives of 1-(4-amino-phenyl)-pyrrolidin-3-yl-amine and 6-(3-amino-pyrrolidin-1-yl)-pyridin-3-yl-amine were identified as potent and functionally active MCH-R1 antagonists. One compound with Ki = 2.3 nM demonstrated good oral bioavailabilit
Huang, Charles Q.,Baker, Tracy,Schwarz, David,Fan, Jun,Heise, Christopher E.,Zhang, Mingzhu,Goodfellow, Val S.,Markison, Stacy,Gogas, Kathleen R.,Chen, Takung,Wang, Xiao-Chuan,Zhu, Yun-Fei
p. 3701 - 3706
(2007/10/03)
Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
The invention relates to substituted N-aryl heterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof. Compounds of the formula I in which the radicals have the stated meanings, the N-oxides and the physiologically tolerated salts thereof and process for the preparation thereof are described. The compounds are suitable for example as anorectic agents.
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(2008/06/13)
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