74885-67-9

Basic information

• Product Name: 4-hydrazinylbenzamide
• Synonyms: 4-hydrazinylbenzamide;Benzamide, 4-hydrazino- (9CI);BenzaMide, 4-hydrazino-;4-hydrazinylbenzamide HCl
• CAS NO: 74885-67-9
• Molecular Formula: C7H9N3O
• Molecular Weight: 151.16586
• Product Categories: AMIDE
• Mol File: 74885-67-9.mol

Chemical Properties

• Boiling Point: 389.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.317±0.06 g/cm3(Predicted)
• PKA: 16.69±0.50(Predicted)
• CAS DataBase Reference: 4-hydrazinylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydrazinylbenzamide(74885-67-9)
• EPA Substance Registry System: 4-hydrazinylbenzamide(74885-67-9)

Safety Data

• Hazardous Substances Data: 74885-67-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
4-hydrazinylbenzamide is used as a potential anti-cancer agent for its capacity to inhibit enzymes that drive the growth and proliferation of cancer cells. This makes it a candidate for the development of new cancer therapies.
Used in Chemical Synthesis:
The hydrazine functional group in 4-hydrazinylbenzamide is utilized as a versatile building block in the synthesis of other organic compounds, contributing to the creation of novel chemical entities for various applications.
Used in Medicinal Chemistry:
4-hydrazinylbenzamide serves as a key intermediate in the design and synthesis of new pharmaceuticals, particularly those targeting cancer treatment, due to its enzyme-inhibiting properties.
Used in Biochemistry:
In the field of biochemistry, 4-hydrazinylbenzamide is applied in studies related to enzyme mechanisms and the development of biochemical assays to understand its interactions with biological systems.
Used in Organic Synthesis:
4-hydrazinylbenzamide is employed as a reactant in various organic synthesis processes, taking advantage of its reactivity and the potential for functional group transformations.

Upstream product

• 2835-68-9 4-aminobenzamide 

Downstream Products

• 40948-51-4 C₁₁H₁₁N₃O₂ 

Relevant articles and documents

Methods and Compositions for Modulating P300/CBP Activity

The present invention relates to a method for identifying compounds that modulate the activity of p300/CBP. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified lysine-CoA inhibitor binding site, L1 loop, electronegative pocket, or electronegative groove of the HAT domain of p300/CBP and testing the compound for its ability to modulate the activity of p300/CBP. Compositions and methods for preventing or treating diseases or disorders associated with p300/CBP are also provided as is a method for producing a semi-synthetic HAT domain.

Virtual ligand screening of the p300/CBP histone acetyltransferase: Identification of a selective small molecule inhibitor

The histone acetyltransferase (HAT) p300/CBP is a transcriptional coactivator implicated in many gene regulatory pathways and protein acetylation events. Although p300 inhibitors have been reported, a potent, selective, and readily available active-sitedirected small molecule inhibitor is not yet known. Here we use a structure-based, in silico screening approach to identify a commercially available pyrazolone- containing small molecule p300 HAT inhibitor, C646. C646 is a competitive p300 inhibitor with a Ki of 400 nM and is selective versus other acetyltransferases. Studies on site-directed p300 HAT mutants and synthetic modifications of C646 confirm the importance of predicted interactions in conferring potency. Inhibition of histone acetylation and cell growth by C646 in cells validate its utility as a pharmacologic probe and suggest that p300/CBP HAT is a worthy anticancer target.