Synthesis of n-alkyl-n-(1-hydroxyperoxyalkyl)nitrosamines by oxygenation of lithiated dialkylnitrosamines
N-Alkyl-N(1-hydroperoxyalkyl)nitrosamines were synthesized from N,N-dialkylnitrosamines by lithiation with lithium diisopropylamide, followed by oxygenation with oxygen in good yields.
FORMATION OF N-ALKYL-N-(1-HYDROPEROXYALKYL)NITROSAMINES FROM N-ALKIL-N-(1-ACETOXYALKYL)NITROSAMINES
N-Alkyl-N-(1-hydroperoxyalkyl)nitrosamines were prepared by treatment of the corresponding 1-acetoxyalkyl nitrosamines with hydrogen peroxide in acetic acid through an acid-catalyzed nucleophilic substitution.