- Synthesis of 2-amino-substituted-1,3,4-thiadiazoles via 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) mediated intramolecular C-S bond formation in thiosemicarbazones
-
An effective oxidative intramolecular cyclization (C-S bond formation) of thiosemicarbazones using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) has been developed to afford a diverse array of 2-amino-substituted-1,3,4-thiadiazoles. The attractive featu
- Singh, Sarangthem Joychandra,Rajamanickam, Suresh,Gogoi, Anupal,Patel, Bhisma K.
-
supporting information
p. 1044 - 1047
(2016/02/18)
-
- Synthesis of some 1,3,4-thiadiazole derivatives as inhibitors of Entamoeba histolytica
-
In the quest for potent anti-amoebic agents, some 1,3,4-thiadiazole derivatives were synthesized and characterized by spectral data. The purity of the compounds was confirmed by elemental analysis. All the compounds were screened in vitro against HM1:IMSS strain of Entamoeba histolytica by microdilution method. The results revealed that compounds 1 (IC50 = 0.670 μM), 3 (IC50 = 1.60 μM) and 8 (IC50 = 0.522 μM) had much better anti-amoebic activity than the reference drug metronidazole (IC50 = 1.80 μM). Further, cytotoxicity of the compounds having IC50 value less than metronidazole was assessed by MTT assay on human breast cancer MCF-7 cell line and all the compounds were found low cytotoxic in the concentration range of 2.5-250 μM. Preliminary results indicate that these three compounds (1, 3 and 8) may be subjected to further investigations and it may be hoped that the present study will stimulate efforts towards the development of novel effective anti-amoebic agents.
- Siddiqui, Shadab Miyan,Salahuddin, Attar,Azam, Amir
-
p. 1305 - 1312
(2013/04/10)
-
- Efficient synthesis of 1,3,4-thiadiazoles using hydrogen bond donor (thio)urea derivatives as organocatalysts
-
(Chemical Equation Presented) A simple and efficient procedure for the synthesis of 1,3,4-thiadiazoles has been achieved using thiourea as organocatalyst. In this study, the steric and electronic effects using structurally different derivatives of urea and thiourea in different solvents were evaluated. The best yields and the rate of the reactions were obtained using 30 mol % of thiourea as catalyst in acetonitrile at room temperature. The molecular structures of the products were established by 1H and 13C NMR spectral data.
- Rostamizadeh, Shahnaz,Aryan, Reza,Ghaieni, Hamid Reza,Amani, Ali Mohammad
-
experimental part
p. 616 - 623
(2010/07/18)
-
- An efficient one-pot procedure for the preparation of 1,3,4-thiadiazoles in ionic liquid [Bmim]BF4 as dual solvent and catalyst
-
The one-pot three component condensation of hydrazine hydrate with substituted phenylisothiocyanates followed by the addition of substituted benzaldehydes in the presence of ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim]BF4)
- Rostamizadeh, Shahnaz,Aryan, Reza,Ghaieni, Hamid R.,Amani, Ali M.
-
p. 320 - 324
(2008/09/19)
-
- Indenoxadiazine, indenopyrazole and spiro triazole derivatives from (substituted ylidene)-N-phenylhydrazine carbothioamides
-
In a multistep reaction, indeno[2,1-e][1,3,4]oxadiazine-9-one, oxoindeno[1,2-c]- pyrazolecarbothioamide, (thioxo-1,2,4-triazaspiro[4.5] decadienylidene)malononitrile and spiro-(fluorine-9,3′-[1,2,4]triazoline)- 5′-thione derivatives have been formed from a series of (substituted ylidene)-N-phenylhydrazinecarbothioamides 1a-e with (1,3-dioxo-2,3-dihydro-1H- inden-2-ylidene)propanedinitrile, 7,7′,8,8′-tetracyanoquinodimethane and (2,4,7-trinitro-9H-fluoren-9-ylidene)propanedinitrile in aerated pyridine. Rationales of these conversions involving the nucleophilic reactions, condensation, dehydrogenation and oxidation are presented.
- Hassan, Alaa A.,Shehata, Hamdy S.
-
p. 629 - 635
(2008/09/19)
-
- 1,3,4-Thiadiazole derivatives. Synthesis, structure elucidation, and structure-antituberculosis activity relationship investigation
-
A series of 2,5-disubstituted-1,3,4-thiadiazoles were synthesized, the compounds structures were elucidated and screened for the antituberculosis activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system. Among the tested compounds, 2-phenylamino-5-(4-fluorophenyl) -1,3,4-thiadiazole 22 showed the highest inhibitory activity. The relationships between the structures of compounds and their antituberculosis activity were investigated by the Electronic-Topological Method (ETM) and feed forward neural networks (FFNNs) trained with the back-propagation algorithm. As a result of the approach, a system of pharmacophores and anti-pharmacophores has been found that effectively separates compounds of the examination set into groups of active and inactive compounds. The system can be applied to the screening and design of new active compounds possessing skeletons similar to those used in the present study.
- Oru?, El?in E.,Rollas, Sevim,Kandemirli, Fatma,Shvets, Nathaly,Dimoglo, Anatholy S.
-
p. 6760 - 6767
(2007/10/03)
-
- RING TRANSFORMATION OF HETEROCYCLRS: PART 3. A CONVERSION OF 4-AMINO-Δ2-1,2,4-OXADIAZOLINES INTO 2-ARYLAMINO-1,3,4-THIADIAZOLES AND OXAANALOGUES
-
4-Amino-Δ2-1,2,4-oxadiazolines (1) are transformed into the corresponding 2-arylamino-1,3,4-oxadiazoles (5) or thiadiazoles (6) via reaction with phenyl isocyanate ( or phenyl isothiocyanate), followed by brief treatment of the resulting adducts (2 and 3) with trifluoroacetic anhydride at ambient temperature.Treatment of compounds (1) with trifluoroacetic anhydride gave 2-trifluoromethyl-1,3,4-oxadiazoles (8).
- Hussein, Ahmad Q.,El-Abadelah, Mustafa M.,Nazer, Musa Z.,Awadallah, Adel M.
-
p. 981 - 990
(2007/10/02)
-