cas 74976-31-1, 6-Chloro-5-Azaindole | Articles data ｜lookchem

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74976-31-1

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TYK2 INHIBITORS AND USES THEREOF
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
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Paragraph 0477; 0484; 0485

(2016/09/26)

COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS
The present application provides novel optionally substituted fused pyridine and pyrimidine bicyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating FAK and/or Src activity by administering a therapeutically effective amount of one or more of the compounds to a subject. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the FAK and/or Src pathway. Advantageously, these compounds perform as dual FAK and/or Src inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.
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(2015/03/28)

New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy.
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Page/Page column 49-50

(2009/10/21)

SYNTHESIS AND PHARMACOLOGIC STUDY OF 6-AMINO DERIVATIVES OF 5-AZAINDOLINE
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Azimov, V. A.,Bychikhina, N. N.,Polezhaeva, A. I.,Mashkovskii, M. D.,Yakhontov, L. N.
p. 308 - 313
(2007/10/02)

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Chemical Properties

Melting Point: 193-194 °C(Solv: benzene (71-43-2))
Boiling Point: 335.8 °C at 760 mmHg
Flash Point:187.2 °C
Density: 1.425 g/cm³
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Vapor Pressure: 0.000228mmHg at 25°C
Refractive Index: 1.703
PKA: 14.30±0.40(Predicted)
PSA: 28.68000
LogP: 2.21630

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