75001-84-2

Basic information

• Product Name: 3-(4-Acetyl-piperazin-1-yl)-4-fluoroaniline
• Synonyms: 3-(4-Acetyl-piperazin-1-yl)-4-fluoroaniline;1-[4-(5-amino-2-fluorophenyl)-1-piperazinyl]Ethanone
• CAS NO: 75001-84-2
• Molecular Formula: C₁₂H₁₆FN₃O
• Molecular Weight: 237.27
• Mol File: 75001-84-2.mol

Chemical Properties

• Melting Point: 132 °C(Solv: benzene (71-43-2))
• Boiling Point: 461.2°C at 760 mmHg
• Flash Point: 232.7°C
• Appearance: /
• Density: 1.245g/cm³
• Vapor Pressure: 1.09E-08mmHg at 25°C
• Refractive Index: 1.58
• PKA: 5.43±0.10(Predicted)
• CAS DataBase Reference: 3-(4-Acetyl-piperazin-1-yl)-4-fluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Acetyl-piperazin-1-yl)-4-fluoroaniline(75001-84-2)
• EPA Substance Registry System: 3-(4-Acetyl-piperazin-1-yl)-4-fluoroaniline(75001-84-2)

Safety Data

• Hazardous Substances Data: 75001-84-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-Acetyl-piperazin-1-yl)-4-fluoroaniline is used as a potential drug candidate for the treatment of neurological disorders, leveraging its pharmacological properties to address specific conditions affecting the nervous system.
Used in Antipsychotic Therapy:
In the field of psychiatry, 3-(4-Acetyl-piperazin-1-yl)-4-fluoroaniline is utilized as an antipsychotic agent, potentially offering therapeutic benefits for individuals with psychotic disorders by modulating relevant neurotransmitter systems.
Used in Antimicrobial Applications:
3-(4-Acetyl-piperazin-1-yl)-4-fluoroaniline is also considered for its potential as an antibacterial and antifungal agent, suggesting its use in combating microbial infections, which could be particularly valuable in the development of new antibiotics and antifungal medications to address drug resistance.
The versatility of 3-(4-Acetyl-piperazin-1-yl)-4-fluoroaniline, stemming from its unique structure and properties, positions it as a compound of interest across multiple sectors within the pharmaceutical industry, each application targeting different therapeutic goals.

InChI:InChI=1/C12H16FN3O/c1-9(17)15-4-6-16(7-5-15)12-8-10(14)2-3-11(12)13/h2-3,8H,4-7,14H2,1H3

Upstream product

• 75001-48-8 1-acetyl-4-(2-fluoro-5-nitrophenyl)piperazine 
• 75012-63-4 1-acetyl-4-(o-fluorophenyl)piperazine 
• 1011-15-0 1-(o-fluorophenyl)piperazine 
• 13889-98-0 N-acetylpiperidine 
• 367-21-5 3-chloro-4-fluorophenylamine 

Relevant articles and documents

A new organosilylpolyphosphoric reagent, its preparation and application to the process of synthesis of 3-carboxyquinolones or azaquinolones and their salts

A process for the preparation of new organosilylpoly-phosphates from the reaction of phosphorus pentoxide with a siloxane or alkyloxysilane to obtain, in solution, reagents the composition of which is [P2O5]N[SILANE], where 1 N 10 where N is a function of temperatu-re, reaction time and solvent, being applied to the modulation of cyclization reaction of N-susbtituted aminomethylenemalonates leading to quinolones or azaqui-nolones. The N-substituted aminomethylenemalonates are prepared by the reaction of anilines with dialkyl trimethylsilyloxy-methylene-malonates.

Structure-Activity Relationships of Antibacterial 6,7- and 7,8-Disubstituted 1-Alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic Acids

Previous quantitative and qualitative structure-activity studies in antibacterial monosubstituted 1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids prompted us to synthesize the 6,7,8-polysubstituted compounds.In this paper, the preparation and antibacterial activity of the 6,7- and 7,8-disubstituted compounds and their derivatives are described.Among these compounds, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid (34) possessed many significant activities and was more active than oxolinic acid (84) against Gram-positive andGram-negative bacteria.Structure activity relationships are discussed.