75055-14-0

Basic information

• Product Name: 8-Methoxy-3-(1H-tetrazol-5-yl)coumarin
• Synonyms: 8-Methoxy-3-(1H-tetrazol-5-yl)coumarin
• CAS NO: 75055-14-0
• Molecular Formula: C11H8 N4 O3
• Molecular Weight: 244.21
• Mol File: 75055-14-0.mol

Chemical Properties

• Boiling Point: 550.6°C at 760 mmHg
• Flash Point: 286.8°C
• Appearance: /
• Density: 1.514g/cm³
• Vapor Pressure: 3.6E-12mmHg at 25°C
• Refractive Index: 1.66
• CAS DataBase Reference: 8-Methoxy-3-(1H-tetrazol-5-yl)coumarin(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Methoxy-3-(1H-tetrazol-5-yl)coumarin(75055-14-0)
• EPA Substance Registry System: 8-Methoxy-3-(1H-tetrazol-5-yl)coumarin(75055-14-0)

Safety Data

• Hazardous Substances Data: 75055-14-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H8N4O3/c1-17-8-4-2-3-6-5-7(10-12-14-15-13-10)11(16)18-9(6)8/h2-5H,1H3,(H,12,13,14,15)

Upstream product

• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 109-77-3 malononitrile 

Relevant articles and documents

An efficient synthesis of 3-(1H-tetrazol-5-yl)coumarins (=3-(1H-tetrazol-5-yl)-2H-1-benzopyran-2-ones) via domino knoevenagel condensation, Pinner reaction, and 1,3-dipolar cycloaddition in water

A novel straightforward synthesis of 3-(1H-tetrazol-5-yl)coumarins (=3-(1H-tetrazol-5-yl)-2H-1-benzopyran-2-ones) 6 via domino Knoevenagel condensation, Pinner reaction, and 1,3-dipolar cycloaddition of substituted salicylaldehydes (=2-hydroxybenzaldehydes), malononitrile (propanedinitrile), and sodium azide in H2O is reported (Scheme1 and Table2). This general protocol provides a wide variety of 3-(1H-tetrazol-5-yl)coumarins in good yields under mild reaction conditions.

3-(Tetrazol-5-yl), 4-methyl-8-alkoxy coumarins and anti-allergic compositions thereof

Coumarin derivatives of the general formula: STR1 wherein R is hydrogen atom, an alkyl group or an alkenyl group, R1 is hydrogen atom, an alkyl group, an alkenyl group or an alkoxy group, and the OR and R1 groups each are substituted at any of the 5, 6, 7 and 8 positions of the coumarin ring, and the salt thereof. The compounds are useful as antiallergic agent for preventing and treating allergic diseases.