- Method for preparing coupling arene from aryl halide by ionizing, discharging and coupling
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The invention discloses a method for preparing coupling arene from aryl halide by ionizing, discharging and coupling. The method comprises the following steps: placing a magnetic stirrer into a three-necked flask and adding aryl halide occupying 1/2 flask, thereby finishing the assembling of an ionizing reaction device; placing the ionizing reaction device into an oil bath pan, introducing inert gas into a reaction system, removing air from the reaction system, starting stirring and heating in the oil bath pan to make aryl halide flow back, and meanwhile, introducing water into a ball-shaped condensation pipe for cooling; starting a high-voltage power generator, and introducing powerful arc generated into the three-necked flask through a metal electrode, thereby ionizing and decomposing aryl halide steam and generating a coupling arene compound; stopping ionizing and heating when solids are separated or the backflow of aryl halide is slowed in a round-bottom flask, and then ending the reaction; recrystallizing or performing reduced pressure distillation purification on the coupling arene product in the flask, thereby acquiring the coupling arene product. The method disclosed by the invention has the advantages of low cost, high efficiency, environmental protection, and the like.
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Paragraph 0029-0043; 0049-0053
(2017/09/26)
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- MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF
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Provided are compounds that are modulators of C3a receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, the compounds are pyridones. In certain embodiments, provided are methods for treatment or amelioration of diseases associated with modulation of C3a receptor activity.
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Page/Page column 84
(2008/12/07)
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- Probing the active catalytic sites of zeolites with benzyl chloride
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Zeolites contain numerous catalytic sites. In order to conduct organic chemistry properly, it is necessary to know which site catalyzes the reaction. The conversion of benzyl chloride was tested as a probe reaction. Different products are obtained when th
- Van Herwijnen, Hendrikus W.G,Brinker, Udo H
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p. 4963 - 4967
(2007/10/03)
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- Lithium tetrakis(pentafluorophenyl)borate-catalyzed Friedel-Crafts benzylation reactions
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Lithium tetrakis(pentafluorophenyl)borate [LiB(C6F5)4], a neutral salt, effectively catalyzed Friedel-Crafts benzylation reactions of aromatic compounds with benzyl chloride or mesylate and their substituted derivatives. The LiB(C6F5)4-catalyzed reactions proceeded more efficiently in the coexistence of magnesium oxide.
- Mukaiyama, Teruaki,Nakano, Masakazu,Kikuchi, Wataru,Matsuo, Jun-Ichi
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p. 1010 - 1011
(2007/10/03)
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