- AZABENZIMIDAZOLE DERIVATIVES AS AMP PROTEIN KINASE AGONISTES
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The present invention relates to compounds of general formula I, wherein the group R1, R2, X, Y and Z are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the AMP-activated protein kinase (AMPK) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
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Page/Page column 53
(2016/02/29)
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- A new synthesis of enantiomerically pure n-alkyl 4-bromobenzenesulfinates and their configurational assignment
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(S)-(-)-α,α-diphenyl-2-pyrrolidinemethanol reacts with 4-bromobenzenesulfinyl chloride to give a single diastereomer of the corresponding sulfinamide in high yield. By an acidic alcoholysis of the sulfinamide with primary alcohols one obtains enantiomerically pure new (R)-(+)-n-alkyl 4-bromobenzenesulfinates. The configurations of the sulfinamide and the sulfinates derived from it have been determined by 1H-NMR and molecular modeling.
- Nicoud,Cherkaoui
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p. 1941 - 1946
(2007/10/03)
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