Benzothiazole Derivatives : Part XI - Synthesis and Antiinflammatory Activity of Some 2-(3',5'-Dimethyl-4'-substituted-pyrazol-1'-yl)benzothiazoles
A number of 2-(4'-alkyl-3',5'-dimethylpyrazol-1'-yl)benzothiazoles (Ia-x) and 2-(4'-carbethoxymethyl-3',5'-dimethylpyrazol-1'-yl)benzothiazoles (IIa-f) have been synthesised by the condensation of 2-hydrazinobenzothiazoles with 3-substituted pentane-2,4-diones.Alkaline hydrolysis of II gives the corresponding acids (IVa-f).Some of the compounds show low to moderate antiinflammatory activity.
Sawhney, S. N.,Tomer, R. K.,Prakash, Om,Prakash, Indra,Singh, S. P.
p. 314 - 316
(2007/10/02)
Carbon-13 Nuclear Magnetic Resonance Spectra of Some 2-(3',5'-Dimethylpyrazol-1'-yl)benzothiazoles
13C NMR spectra of 6-substituted 2-(3',5'-dimethylpyrazol-1'-yl)benzothiazoles (Ia-d; R: H, OCH3, Cl and F) have been recorded, and complete spectral assignments made on the basis of proton-decoupled, coupled and selectively coupled spectra.
Sawhney, S. N.,Tomer, R. K.,Prakash, Indra,Singh, S. P.
p. 395 - 396
(2007/10/02)
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