- Dual Ligand-Enabled Nondirected C-H Cyanation of Arenes
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Aromatic nitriles are key structural units in organic chemistry and, therefore, highly attractive targets for C-H activation. Herein, the development of an arene-limited, nondirected C-H cyanation based on the use of two cooperatively acting commercially available ligands is reported. The reaction enables the cyanation of arenes by C-H activation in the absence of directing groups and is therefore complementary to established approaches.
- Chen, Hao,Mondal, Arup,Wedi, Philipp,Van Gemmeren, Manuel
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p. 1979 - 1984
(2019/02/19)
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- Preparation method of eluxadoline intermediate
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The invention discloses a preparation method of an eluxadoline intermediate. The structure of the intermediate corresponds to a formula IV as shown in the specification. According to the method, 2-halogenated-mesitylene in a formula I serves as a raw material, bromination and cyanation reaction is performed, and finally, the intermediate in the formula IV is obtained. According to the synthesis method, raw materials are inexpensive, easy to obtain and low in cost, scale-up production is facilitated, reaction conditions are mild, and safety coefficient and yield are high.
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- PROCESS FOR THE PREPARATION OF PROTECTED L-ALANINE DERIVATIVES
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The present invention is directed to a novel process for the preparation of protected L-alanine derivatives, useful as intermediates in the synthesis of compounds useful as mu/delta opioid modulators.
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Page/Page column 30-31
(2010/06/17)
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- Synthesis and spectroscopic properties of arene-substituted pyrene derivatives as model compounds for fluorescent polarity probes
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In this paper, the syntheses of a variety of substituted phenyl pyrenes 5a-n by Suzuki cross-coupling and of two decoupled analogues 10 and 17 are reported. These compounds have been investigated by fluorescence spectroscopy. The solvatochromism of their emission bands (Stokes shift) and the quantum yields in methylcyclohexane and acetonitrile have been determined. Furthermore, the crystal structure of a pyrenyl-tris(2,2′-bipyridine)ruthenium(II) complex 19 is presented.
- Beinhoff, Matthias,Weigel, Wilfried,Jurczok, Martin,Rettig, Wolfgang,Modrakowski, Claudia,Bruedgam, Irene,Hartl, Hans,Schlueter, A. Dieter
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p. 3819 - 3829
(2007/10/03)
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