- Preparation method of phytol and intermediates thereof
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The invention discloses a preparation method of phytol and intermediates thereof, which comprises the following steps: (1) carrying out esterification rearrangement reaction on isophytol and anhydrideunder the action of perchlorate to obtain phytol ester; and (2) carrying out transesterification on the phytol ester to obtain the phytol. According to the preparation method disclosed by the invention, the total molar yield of the phytol can be up to 88.1%, the generation of potassium acetate or sodium acetate waste solids caused by a potassium hydroxide or sodium hydroxide hydrolysis process isavoided by adopting an ester exchange process, three wastes are effectively controlled, and the method is green and environment-friendly.
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Paragraph 0064-0099
(2021/03/18)
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- Full racemic phytol composition, and preparation method and application thereof
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The present invention provides a full racemic phytol composition with high E-configuration content, a preparation method of the full racemic phytol composition and applications of the full racemic phytol composition in preparation of vitamin K1. The full racemic phytol composition comprises Z-configuration full racemic phytol and E-configuration full racemic phytol, wherein a ratio of Z/(Z+E) is less than or equal to 15%. The preparation method comprises the following steps: with isophytol as a raw material, performing halogenation, esterification, ester group removal reaction and the like toobtain the full racemic phytol composition with high E-configuration content.
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- Synthesis method and method for synthesizing plant alcohol, isoplant alcohol and geranyl geraniol by using intermediate farnesylacetone (by machine translation)
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The invention relates to a synthesis method of intermediate farnesyl acetone and a method for synthesizing vitamin E, vitamin K1, vitamin K2 side chain isovegetable alcohol, plant alcohol and geranyl geraniol by using farnesyl acetone, and concretely relates to hydrogenation of 5 - farnesyl -2 - acetone and farnesyl acetone through three Grignard reaction to obtain plant ketone. The farnesyl acetone reacts with the vinyl chloride Grignard reagent to obtain geranyl linalool, the aromatic leaf-based geraniol is rearranged under acid catalysis, or farnesyl acetone is directly reacted with the hydroxyl-protected 2 - chloroethanol Grignard reagent to obtain geraniol. The plant alcohol is reacted with the vinyl chloride Grignard reagent to obtain the plant alcohol, and the plant alcohol is directly reacted with the hydroxyl-protected 2 - chloroethanol Grignard reagent to obtain the plant alcohol. The method has the advantages of cheap and easily available starting materials, short synthetic process steps, low product cost and the like. (by machine translation)
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- Development of synthetic routes to D,L-α-tocopherol (vitamin E) from biologically produced geranylgeraniol
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The use of the biologically derived diterpene alcohol geranylgeraniol was explored as an alternative to petrochemical-based isophytol as a side-chain synthon for producing D,L-α-tocopherol. Two routes were studied, both of which begin with allylic epoxidation followed by olefin hydrogenation to give epoxyphytol. Epoxyphytol can be reduced with Red-Al to provide phytan-1,3-diol which upon acid-catalyzed condensation with trimethylhydroquinone gives vitamin E in fair yield. In a higher-yielding process, epoxyphytol was deoxygenated with methylrhenium trioxide/triphenylphosphine to generate a mixture of phytol and isophytol (> 90% yield from geranylgeraniol). This mixture can serve as a "plug-in" replacement for isophytol in the final step of the currently practiced vitamin E chemistry. The use of methylrhenium trioxide to catalyse dehydration of vinyl dialkyl carbinols to 1,3-dienes was also demonstrated.
- Hyatt, John A.,Kottas, Gregg S.,Effler, Janet
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p. 782 - 787
(2013/09/06)
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