- Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages
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Specialized pro-resolving mediators (SPMs) comprise lipid mediators (LMs) produced from polyunsaturated fatty acids (PUFAs) via stereoselective oxygenation particularly involving 12/15-lipoxygenases (LOXs). In contrast to pro-inflammatory LMs such as leuk
- Cala Peralta, Antonio,Helesbeux, Jean-Jacques,Hoff, Daniel,Hofstetter, Robert Klaus,Jordan, Paul M.,Koeberle, Andreas,Kretzer, Christian,Meyer, Katharina P. L.,Richomme, Pascal,Schuster, Daniela,Seraphin, Denis,Stuppner, Hermann,Temml, Veronika,Viault, Guillaume,Werner, Markus,Werz, Oliver
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- Practical metal-free synthesis of chalcone derivatives via a tandem cross-dehydrogenative-coupling/elimination reaction
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Metal-free synthesis of chalcone derivatives through a tandem cross-dehydrogenative-coupling/elimination reaction is described. A simple and inexpensive ammonium persulfate salt enables the reaction between ketones and benzylamines to proceed with high stereoselectivity and good functional group compatibility.
- Wei, Yu,Tang, Jinghua,Cong, Xuefeng,Zeng, Xiaoming
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supporting information
p. 3165 - 3169
(2013/11/06)
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- COMPOUNDS, THEIR SYNTHESES, AND THEIR USES
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Embodiments of the present invention provide compounds (such as Formula (I) compounds, Formula (II) compounds, and various embodiments thereof). Compositions comprising those compounds are also provided. Methods for their preparation are included. Also, uses of the compounds are included, such as administering and treating diseases (e.g., cancer and infections).
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Page/Page column 41
(2010/04/03)
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- Synthesis, cytotoxicity, and anti-Trypanosoma cruzi activity of new chalcones
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Synthesis of a cytotoxic dihydrochalcone, first isolated from a traditional Amazonian medicinal plant Iryanthera juruensis Warb (Myristicaceae), followed by a comprehensive SAR analysis of saturated and unsaturated chalcone synthetic intermediates, led to the identification of analogues with selective and significant in vitro anti-Trypanosoma cruzi activity. Further SAR studies were undertaken with the synthesis of 21 new chalcones containing two allyloxy moieties that resulted in the discovery of 2′,4′-diallyloxy- 6′-methoxy chalcones with improved selectivity against this parasite at concentrations below 25 μM, four of which exhibited a selectivity index greater than 12.
- Aponte, José C.,Verástegui, Manuela,Málaga, Edith,Zimic, Mirko,Quiliano, Miguel,Vaisberg, Abraham J.,Gilman, Robert H.,Hammond, Gerald B.
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experimental part
p. 6230 - 6234
(2009/09/25)
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- Syntheses of Two New Naturally Occurring Dihydrochalkones, Uvangolatin and 2',4'-Dihydroxy-4,6'-dimethoxydihydrochalkone
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The structures proposed for the two naturally occurring dihydrochalkones, uvangolatin isolated from Uvaria angolensis as 2',4'-dihydroxy-6'-methoxydihydrochalkone (I) and another dihydrochalkone isolated from Iryanthera laevis as 2',4'-dihydroxy-4,6'-dime
- Bhardwaj, D. K.,Jain, R. K.,Munjal, Anita,Prashar, Meenu
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p. 476 - 477
(2007/10/02)
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