New carboxylic acid amides of the pyrrole series: Synthetic routes and biological aspects
Complex II inhibitors play an important role in agrochemical fungicide research and have been known for more than 40 years. With the introduction of ortho-substituted heterocyclic amides, a breakthrough in activity level and spectrum within this class was achieved. In the meantime all major agrochemical companies have entered this field. In this paper, a special complex II subclass, the pyrrole carboxamides, will be introduced in more detail and the synthesis of selected compounds as well as a short biological SAR analysis of the pyrrole subclass will be discussed.
Walter, Harald
scheme or table
p. 351 - 362
(2009/01/31)
Reactions of trifluoromethyl ketones. VIII. Investigation of steric effects of a trifluoromethyl group through ene reaction of trifluoromethyl ketones
In the course of our study on the ene reaction of trifluoromethyl ketones, a trifluoromethyl group has been observed to behave as a larger substituent than commonly believed in the biomedicinal field. To estimate the steric eflect of a trifluoromethyl gro
Nagai,Nishioka,Koyama,Ando,Miki,Kumadaki
p. 593 - 598
(2007/10/02)
Fungicidal Pyridine Derivatives, IV. α-Trifluoromethyl-3-pyridinemethanols
The synthesis of a series of the title compounds is described applying the addition of 3-pyridyllithium to appropriate trifluoromethylalkanones (path 1) and addition of lithiumorganyls to 2,2,2-trifluoro-1-(3-pyridyl)-ethanone (path 2), respectively.Keywords.Fungicides; α-Trifluoromethyl-pyridinemethanols.
Sauter, Fritz,Stanetty, Peter,Ramer, Wolfgang,Sittenthaler, Wilhelm
p. 879 - 885
(2007/10/02)
2-[Trifluoroethylamine]oxazolines
This invention relates to trifluorethylamines and to a process for producing the same. These trifluorethylamines are substituted on the nitrogen atom with a lower alkyl or a cyclo lower alkyl radical. They are endowed with interesting pharmacologi
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(2008/06/13)
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